Proteasome and Organs Ischemia-Reperfusion Injury: A Review | Chapter 7 | Recent Research Advances in Biology Vol. 10

 Organ failure needs the transplanting of functional organs from donors to treat patients. The development of organ preservation solutions enhanced transplantation methodology over time. Ischemia occurs when organs are stored in preservation solutions, resulting in a lack of oxygen and nutrition, which damages the tissues. When the organ is ready for transplantation, reperfusion promotes tissue damage by increasing oxidative stress, endoplasmic reticulum stress, and inflammation. The success of transplanting is decreasing. The inclusion of a proteasome inhibitor in the preservation solution, on the other hand, reduced the damage caused by the ischemia-reperfusion process. The proteasome is a protein structure that regulates inflammation and aids in the removal of damaged proteins. The purpose of this review is to outline the proteasome's involvement in protecting organs from ischemia-reperfusion injury, as well as the pharmaceutical substances that regulate the proteasome. The success of transplanting is decreasing. The inclusion of a proteasome inhibitor in the preservation solution, on the other hand, reduced the damage caused by the ischemia-reperfusion process. The proteasome is a protein structure that regulates inflammation and aids in the removal of damaged proteins. The purpose of this review is to outline the proteasome's involvement in protecting organs from ischemia-reperfusion injury, as well as the pharmaceutical substances that regulate the proteasome.

Author (s) Details

Joan Oliva
Clinical Research Department, Emmaus Medical, Torrance, CA 90503, USA.

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Therapeutic Properties of Mesenchymal Stem Cell on Organ Ischemia-reperfusion Injury: A Review | Chapter 6 | Recent Research Advances in Biology Vol. 10

 The scarcity of organ donors is a big global issue. Organ failure necessitates the use of functional organ transplants. Organs are kept for varying periods of warm and cold ischemia time, which necessitates their placement in a preservation device. The organs are damaged during ischemia and reperfusion due to a lack of oxygen during the ischemia step and oxidative stress during the reperfusion step. To avoid or reduce the severity of injuries, many approaches have been created. Cold static preservation solutions, which comprise the inclusion of numerous chemical compounds, were initially created to maximise cold static preservation. Injuries to the organ Mesenchymal stem cells (such as bone marrow stem cells, adipose-derived stem cells, and umbilical cord stem cells) have been shown to be effective in the healing of damaged organs. The use of bone marrow stem cells, adipose-derived stem cells, and umbilical cord stem cells to prevent or reduce ischemia-reperfusion damage will be the focus of this review.

 
Author (s) Details

Joan Oliva
Clinical Research Department, Emmaus Medical, Torrance, CA 90503, USA.

View Book :-  https://stm.bookpi.org/RRAB-V10/article/view/2136

Significance of Extra Hepatic Portal Vein Variations in Hepatopancreatic Surgeries | Chapter 3 | Highlights on Medicine and Medical Science Vol. 3

 Introduction: When performing pancreas and duodenum surgeries, it is critical to understand the variations in the portal vein's path. It can also be used to treat traumatic mesentery rupture. Awareness of portal vein variations is critical in surgical resection and transplantation, especially during pretreatment planning, to reduce the complication rates of the surgical and radiological treatments. Furthermore, an in-depth understanding of portal vein variations is essential in determining the technical feasibility of surgical interventions such as liver transplantation, portal vein embolization prior to hepatectomy, and postoperative care. The purpose of this study is to examine the anatomical variations of the portal vein, correlate the findings with clinical problems, and provide a good ontological explanation. Materials and Methods: Twenty-four cadavers embalmed in 10% formalin were obtained from the department of anatomy and dissected for this study. Variations were meticulously cleaned and photographed. Among the variations observed were the formation of the portal vein by the confluence of the superior mesenteric, inferior mesenteric, and splenic veins (1 case), as well as the inferior mesenteric vein terminating in the superior mesenteric vein (6 cases). Conclusion: The purpose of this study was to determine the approximate percentage of incidence of major variations in portal vein formation. By being aware of such variations prior to major abdominal procedures, it is possible to avoid severe intraoperative hemorrhage. Among the variations observed were the formation of the portal vein by the confluence of the superior mesenteric, inferior mesenteric, and splenic veins (1 case), as well as the inferior mesenteric vein terminating in the superior mesenteric vein (6 cases). Conclusion: The purpose of this study was to determine the approximate percentage of incidence of major variations in portal vein formation. By being aware of such variations prior to major abdominal procedures, it is possible to avoid severe intraoperative hemorrhage.

Author (S) Details

Dr. Neelesh Kanasker
Department of Anatomy, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India.

Prof. Preeti Sonje
Department of Anatomy, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India.

Dr. Janhavi Bankar
Dr. D.Y. Patil Medical College, Pune, Maharashtra, India.

Dr. (Mrs.) Vatsalaswamy
Department of Anatomy, Dr. D.Y. Patil Medical College, Pune, Maharashtra, India.

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