Advanced Nanocarriers to Navigate the Blood-brain Barrier: A New Frontier in CNS Drug Delivery | Chapter 3 | Pharmaceutical Science: New Insights and Developments Vol. 6

The central nervous system (CNS) is shielded from threats by the blood-brain barrier (BBB), a selective physiological gatekeeper. It does, however, also provide a serious obstacle to the delivery of therapeutic medicines to the brain, making it difficult to treat neurological conditions such as glioblastoma, epilepsy, and Alzheimer's. With their focused distribution, regulated release, targeted delivery, and improved BBB penetration, nanocarrier-based methods act as a reassuring alternative. This chapter examines drug delivery obstacles, the anatomy of the blood-brain barrier, and the function of advanced nanocarriers, including exosomes, liposomes, dendrimers, and polymeric and lipid nanoparticles. Additionally, it addresses recent developments in receptor-mediated targeting, surface modifications, stimuli-responsive administration, and regulatory issues, as well as future objectives in brain-targeted nanomedicine.

 

Author (s) Details

Venkatalakshmi Ranganathan
Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science & Technology, Chennai-600048, India.

 

Roshni. N
Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science & Technology, Chennai-600048, India.

Preethi. M
Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science & Technology, Chennai-600048, India.

 

Sasikala Chinnappan
Department of Pharmaceutical Biology, UCSI University, Taman Connaught, 56000 Cheras, Malaysia.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v6/5443

Study about Nanosponges- An Emerging Technology| Chapter 4 | Challenges and Advances in Pharmaceutical Research Vol. 2

A Nanosponge is a cutting-edge device that delivers topical and oral drugs in a precise and regulated manner. Nanosponges are nano-polymer spheres that may suspend or trap many compounds in a designed product like a gel, cream, ointment, fluids, or powder. They're then mixed into a finished product. This method allows ingredients to interact, reducing negative effects, improving stability, beauty, and variety in formulations. Nanosponge is a cutting-edge drug delivery system. It is a fundamental support device for the targeted distribution of all sorts of medications, whether lipophilic or hydrophilic. The term 'nanosponge' was coined in the 1990s to describe a nanopore, spongy-like structure that may overcome the limitations of native cyclodextrins (CD), particularly their water solubility. In the years since CD NS was first introduced, researchers have attempted to explain how low molecular weight molecules, high molecular weight molecules, hydrophobic or hydrophilic nature, and their ability to tolerate cyclodextrin changes, cross-connection, and cross-connection molecules can host their behaviour and function. They have achieved significant progress in a variety of industries, including agribusiness, pharmaceuticals, biomedicine, and biotechnology, yet there is no comprehensive NS study available. This report provides an overview of CD NS research, focusing on historical foundations and key concerns ranging from very basic networking in the 1960s to multifunctional polymers in the last 50 years. The strategy taken in this study was to look at historical patterns in NSs in order to better understand their role and envision their future via the examination of various writers and their evaluations.

Author(s) Details:
G. S. Annammadevi,
Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam-530045, India.

Addanki Anusha,
Institute of Pharmacy, GITAM (Deemed to be University), Rushikonda, Visakhapatnam-530045, India.

Please see the link here: https://stm.bookpi.org/CAPR-V2/article/view/6576