Influential Study of Green Tea Leaf Extracts (Camellia sinensis L.) on Male Reproductive System of Albino Rats | Chapter 9 | Current Aspects in Pharmaceutical Research and Development Vol. 4

 The purpose of this study is to see how effective a herbal product called green tea leaf extract is (GTLE). In addition to determining a simple alternative to surgical castration, the goal of this research is to find an easy way out of male castration. This herbal drug, which was used in this study, had a significant functional and morphological impact on the male reproductive system. Wei. H. et almethod .'s was used to make the extract. The extract was given to two distinct experimental animal groups at two different doses during a 26-day period. Following therapy, the weight of the testis was found to be drastically lowered, as compared to the animals' typical weight rise. The treated animals had reduced sperm count and motility when compared to the control animals. Enzymes like SGPT and SGOT, as well as other blood indicators like glucose and protein, were normal in compared to the control group. The treated groups had lower testosterone levels. FSH and LH levels were also altered in the treated groups. Spermatogenesis was hindered, as demonstrated by the breakdown of testicular seminiferous tubules, according to histological testing. GTLE has a significant castrative impact on the male reproductive system in a dose-dependent way, according to the findings of this study.

Author(S) Details

Shyamal Kanti Das
Department of Physiology, Krishnath College, Berhampore, Murshidabad, West Bengal, India.

Soumendra Nath Karmakar
Department of Physiology, Krishnath College, Berhampore, Murshidabad, West Bengal, India.

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Evaluation of Anti-fertility Activity of Ruta montana L. Areal Part Extractin Albino Rats | Chapter 15 | Current Research Trends in Biological Science Vol.4

 

Ruta montana L. a herb from the family Rutaceae, is known in Algeria as “mountain rue” or “Fidjel”
and has been used in folk medicine as an antioxidant, hypoglycemic, antirhematic, antihelmintic,
antiepileptic and antipyretic. The objective of the present study is to evaluate the effect of the aqueous
extract of Ruta montana L. on the fertility in adult male and female rats. Forty healthy adult rats of
both sexes were divided into 4 Groups of 10 rats each. During the treatment period, 100, 300 and 600
mg/kg/day of the extract were orally administered to Groups I, II and III respectively, while the control
group received distilled water and served as control. The daily administration was carried out for a
period of 90 days. The results did not show any significant change in ovaries weight. However, a
significant decrease in testis, epididymis, and seminal vesicles weights was detected, as well as a
reduction in the number and the motility of spermatozoids in rats treated with the doses of 300 and
600 mg/kg. A dose of 300 mg/kg and 600 mg/kg of aqueous extract of Ruta Montana L. was able to
cause a decrease in sexual organs weight of male rats and in the number and the motility of
spermatozoids.

Author (s) Details

Dr. Mounira Merghem
Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, Ferhat Abbas University Setif-1, 19000 Setif, Algeria.

Pr Dr. Saliha Dahamna
Laboratory of Phytotherapy Applied to Chronic Diseases, Faculty of Nature and Life Sciences, Ferhat Abbas University Setif-1, 19000 Sétif 1, Algeria.

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