Showing posts with label rhabdomyolysis. Show all posts
Showing posts with label rhabdomyolysis. Show all posts

Thursday, 13 October 2022

Acute Myopathy Leading to Severe Rhabdomyolysis: A Case Report | Chapter 10 | Current Innovations in Medicine and Medical Science Vol. 4

 The present study highlights and unusual presentation of acute myopathy leading to severe rhabdomyolysis. Despite the obvious advantages of combined antiplatelet and lipid-lowering treatments, a possible inter-action between statins and ticagrelor may lead to myopathy and rhabdomyolysis. A one year and two month old girl was brought to the accident and emergency department with a history of acute generalised weakness of around 12 hours duration. She had been completely well before this episode. The child showed progressive deterioration neurologically, primarily her airway and breathing being involved and hence needing acute respiratory support, but with complete recovery without any neurological deficit. In our patient, though investigated extensively, a cause was not identified and parents declined muscle biopsy. However, viral myositis should be considered as a possible aetiology in our patient.


Author(s) Details:

Dhanasekhar Kesavelu,
Apollo Children’s Hospital, India.

Please see the link here: https://stm.bookpi.org/CIMMS-V4/article/view/8400

Wednesday, 25 May 2022

Stiff Person Syndrome: A Case Report and Review | Chapter 13 | New Horizons in Medicine and Medical Research Vol. 9

 The case centres on a 26-year-old male patient who was admitted to the General Medicine ward for a non-life-threatening ailment. In the previous three days, this patient had had excruciating spasms and stiffness in both legs. The patient was unable to stand up without difficulty as a result of this complaint, and as a result, was unable to walk correctly. He had no history of animal or insect bites or wounds, and his legs were free of infected sores or abscesses. The patient explained that his employment needs him to stand for lengthy periods of time in hot temperatures when asked. However, his symptoms seemed to intensify and spread over time. As a result, he was taken to the General Medicine ward for heat stroke. with rhabdomyolysis. His renal function tests were normal, and his CK levels were > 2000 IU/l.

Overall, the patient appeared stable and fully conscious, well-oriented to time and place, and afebrile. However, he seemed to resist movement and therefore looked rigid in his overall appearance. However, (to avoid using ‘however’ again, you could start with: ‘Despite this, his…’) his symptoms greatly improved to the point of nearly disappearing when he was resting or asleep.  The patient also had to be shifted to the ICU to stabilize his muscle stiffness, where he developed a few complications such as acute kidney injury, severe lactic acidosis, desaturation, tachycardia, and reduced urine output. In the middle of all this, (Or: ‘During all this,’) there was no abnormality seen in neuroimaging or from electrophysiological studies. However, the raised level of anti-GAD antibodies combined with the patient's history and examination findings all pointed towards the patient suffering from Stiff Person Syndrome (SPS). However, since this case was already proving to be both complicated and difficult to diagnose, there must be (or ‘needs to be’) a systematic way of ruling out the other possible causes of the symptoms and the complications that arise in a given patient to make sure that there are no errors in diagnosing the case or intervening accordingly. Failure to do so can complicate the condition and deteriorate the patient’s condition further. Therefore, this case study aims to target those areas that point towards diagnosing this condition early and in a better way. This study also focuses on the possible treatment and management plans that should be systematically carried out on suspected patients of Stiff Person Syndrome to ensure their timely survival and to prevent complications electrophysiological research The patient's history and physical results, together with the patient's elevated anti-GAD antibodies, all pointed to the patient having Stiff Person Syndrome (SPS). However, because this case was already proving to be complicated and difficult to identify, there must be (or 'needs to be') a systematic manner of ruling out other probable causes of symptoms and problems in a specific patient to ensure that no errors in diagnosing or intervening are made. Failure to do so may aggravate the situation and worsen the patient's condition. As a result, the goal of this case study is to focus on the aspects that indicate to identifying this problem earlier and more accurately. This research also looks at various therapy and management strategies that should be used on suspected Stiff Person Syndrome patients in order to ensure their timely survival and avoid complications.

Author(S) Details

Ashraf ALakkad
Department of Internal Medicine, Madinat Zayed Hospital, United Arab Emirates.

Mahmoud Sami
Department of Critical Care, Madinat Zayed Hospital, United Arab Emirates.

Mohamed Salah
Department of Neurology, Madinat Zayed Hospital, United Arab Emirates.

View Book:- https://stm.bookpi.org/NHMMR-V9/article/view/6908


Tuesday, 17 August 2021

Clinical Profile and Incidence of Acute Kidney Injury Due to Hair Dye Poisoning: A Prospective Study | Chapter 15 | New Frontiers in Medicine and Medical Research Vol. 2

 Background: In recent decades, suicides have increased at an alarming rate over the world, claiming the most productive age group in society. India, like the rest of the developing world, is not exempt to the unnecessarily rising death toll.


Methods: For this prospective observational study, 31 patients were enrolled at Osmania General Hospital between November 2011 and October 2013. Patients hospitalised to MICU for alleged hair dye ingestion were enrolled in the study when the exclusion criteria were ruled out. Every patient, or a family member of a patient, gave their informed consent. All standard laboratory investigations were done according to usual clinical procedures and protocols from the time of hospital admission until discharge or death, and patient-related clinical information was entered on the created proforma. The existence of AKI was defined and rated using RIFLE criteria.

The current study examines 31 cases of suicidal hair dye use, with males accounting for 6 (19.35%) and females accounting for 25%. (80.64 percent). In the age group of 21-30 years, males (30%) and females (30%) were shown to have a higher probability of committing suicide (70 percent). In 19% of patients who swallowed more than 50 mL of dye, acute kidney injury demanding hemodialysis developed. Approximately 58 percent of patients were discharged from the hospital in good general health after therapy. Respiratory problems such as pneumonia, ARDS, sepsis, and ARF claimed the lives of four patients.

Conclusions: In the current condition of emerging hair dye poisoning, it is vital for a fast response by lowering the length of stay in the hospital, as well as early management by doctors.

Author (S) Details

P. Ramulu
Department of General Medicine, Osmania Medical College, Hyderabad, Telangana, India.

P. Amruth Rao
National Institute of Nutrition, Hyderabad, Telangana, India.

K. Kanthi Swaroop
Department of General Medicine, Osmania Medical College, Hyderabad, Telangana, India.

K. Paul Marx
Department of Biochemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

Ch. Venkata Ramana Devi
Department of Biochemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

View Book :- https://stm.bookpi.org/NFMMR-V2/article/view/2688