Synthesis and Applications of α-Oxodithioesters | Chapter 6 | Chemistry and Biochemistry: Research Progress Vol. 4

In this chapter, we present the synthesis of α-oxodithioesters and their applications for the synthesis of heterocyclic compounds. At first, we report the synthesis of 2-(methylthio)-3-(het) arylquinoxalines by the cyclocondensation of o-phenylenediamines with α-oxodithioesters catalyzed by p-toluenesulfonic acid (p-TSA) in toluene at 80°C. 2-Acylbenzoxazoles are formed when o-aminophenols react with α-oxodithioesters under similar reaction conditions. Besides, 4-methylthio-5-acylthiazoles are obtained when α-oxodithioesters are reacted with tosylmethyl isocyanide in aqueous alcoholic potassium hydroxide media. Similarly, a reaction between ethyl isocyanoacetate and α-oxodithioesters in ethanol in the presence of DBU-furnished ethyl 5-acylthiazole carboxylates. The p-TSA catalyzed cyclocondensation of anthranilamide with α-oxodithioesters in DMF at 120°C produced 2-acylquinazolin-4(3H)-ones. Finally, a reaction between α-oxodithioesters and anthranilamide in refluxing acetic acid formed 2-acyl-4H-benzo[d][1,3] thiazin-4-ones. 

 

Author (s) Details

Toreshettahally R Swaroop
Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysuru – 570 006, Karnataka, India.

 

Rajaghatta N Suresh
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysuru – 570 006, Karnataka, India.

 

Muddegowda Umashankara
Department of Chemistry, Karnataka State Open University, Muktagangotri, Mysuru - 570 006, Karnataka, India.

 

Kanchugarakoppal S Rangappa
Institution of Excellence, University of Mysore, Manasagangotri, Mysuru - 570 006, Karnataka, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/cbrp/v4/4579

A Renewable Relationship between Epilepsy and Quinazolinones| Chapter 7 | Challenges and Advances in Pharmaceutical Research Vol. 5

 

 There must be a global response to the public health problem of epilepsy. No matter where it occurs in the world, epilepsy affects people of all ages, genders, races, and social backgrounds. The cortical area of the brain's excessive cortical neuron firing frequently results in the epileptic condition. Understanding the different types of epileptic episodes is the first step in determining an accurate epilepsy diagnosis, course of therapy, and prognosis. Particular seizure types or diseases usually respond better to particular medications or surgical methods. The largest difficulty in treating epilepsy is multidrug resistance syndrome and refractory epilepsy because they prevent Anti-Epileptic Drugs (AEDs) from reaching their intended target in the central nervous system. Additionally, the medications that are already on the market have harmful side effects such sleepiness, hepatotoxicity, anaemia, and teratogenicity. It is crucial to find new medications that are both safe and efficient. Analogues of quinazolinones are molecules that can bind to several sites with high affinity and speed up the development of valuable compounds with therapeutic activity. Novel quinazolinone derivatives have been developed by several scientists from across the world and have been virtually screened and evaluated for their potential to cure various types of seizures. They will be extremely important in the future management of epilepsy.

Author(s) Details:

H. S. Al-Salem,
Department of Pharmaceutical Chemistry, King Saud University, Saudi Arabia.

T. O. Mirgany,
Department of Pharmaceutical Chemistry, King Saud University, Saudi Arabia.

Please see the link here: https://stm.bookpi.org/CAPR-V5/article/view/7775