Bioabsorbable Materials for the Future Treatment of Congenital Heart Disease | Chapter 17 | Current Practice in Medical Science Vol. 2

With a focus on the current state of regenerative engineering valves, patches, and regenerative medicine for pulmonary vein stenosis employing bioabsorbable materials, the current study examines the true demands of regenerative medicine from the perspective of paediatric cardiovascular surgery. Bioabsorbable materials made of polymeric compounds have been employed by several regenerative medicine fields to speed up tissue regeneration. Due to their growing potential, these materials are excellent replacements for autologous tissue in cardiovascular applications such valves, patches, sutures, vascular grafts, and defect occlusion devices in the treatment of congenital heart disease. Between their theoretical benefits and actual practical use in congenital heart disease, there is still a substantial gap. Before using these resorbable, synthetic materials in human therapeutic settings, it is crucial to establish their effectiveness and safety in large animal models.

Author(s) Details:

Yuichi Matsuzaki,

Center for Regenerative Medicine, The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA.

Toshiharu Shinoka,

Center for Regenerative Medicine, The Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA and Department of Cardiothoracic Surgery, The Heart Center, Nationwide Children’s Hospital, Columbus, OH, USA.

Please see the link here: https://stm.bookpi.org/CPMS-V2/article/view/7621

Study about Late Follow-Up of Persistent Truncus Arteriosus, after One- Stage Repair, Using a Biological Bicuspid Prosthesis to Pulmonary Valve Reconstruction | Chapter 07 | New Horizons in Medicine and Medical Research Vol. 3

 In a two-month-old girl with Persistent Truncus Arteriosus type I, II, we describe long-term outcomes after a one-stage surgical correction. The procedure involved the modification of the right ventricle and the use of a swine bicuspid pulmonary prosthesis. The patient is in great clinical health, with CF I (NYHA) and normal peripheral oxygen saturation, twenty-six years later. Recent invasive and non-invasive imaging reveals: no intracardiac shunt, increasing right ventricle outlet tract, and distinct pulmonary valve double lesion. Both lungs receive the same amount of pulmonary flow. In some circumstances, patients with truncus arteriosus who have early surgical repair and avoid the use of a valved conduit have a favourable long-term prognosis, requiring no subsequent procedures. Endovascular procedures for implantation of a pulmonary valve stent through a catheter, which are now well standardised, will allow an effective approach in the presence of late obstructions in patients who have undergone right ventricular remodelling without the use of valved conduits in patients who have undergone right ventricular remodelling. Over the course of the long follow-up, it was decided that ventricular remodelling with pulmonary valve repair allowed for the maintenance of right ventricular function and the patient's advancement to functional class I (NYHA) with no restrictions on her physical activity.

Author(S) Details

Miguel Maluf
Cardiovascular Division, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.

View Book:- https://stm.bookpi.org/NHMMR-V3/article/view/6336