Investigating Neurological Symptoms of Infectious Diseases Like COVID-19 Leads to a Deeper Understanding of Neurodegenerative Disorders | Chapter 10 | Current Overview on Disease and Health Research Vol. 2

 

Patients with COVID-19 frequently experience neurological symptoms in addition to typical respiratory symptoms. According to studies, SARS-CoV-2 infection increased alpha-synuclein aggregation, created Lewy-body-like pathology, accelerated the senescence of dopaminergic neurons, and aggravated Parkinson's disease symptoms in patients (PD). Additionally, SARS-CoV-2 infection can cause neuroinflammation, accelerate neurodegeneration in protracted COVID, and increase a person's susceptibility to Parkinson's disease (PD) or parkinsonism. These results imply that the present COVID-19 pandemic may be followed by a post-COVID-19 parkinsonism. This paper reviewed the neurological symptoms and associated findings of COVID-19, related infectious diseases (influenza, AIDS, and prion disease), and neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis), and discussed potential mechanisms underlying the neurological symptoms and the relationship between them. the neurodegenerative illnesses and infectious diseases, as well as the consequences for treatment and prevention of neurodegenerative disorders. Over time, alpha-synuclein "prions" and infections with a variety of microorganisms (such as SARS-CoV-2, influenza A viruses, gut bacteria, etc.) may combine to cause Parkinson's disease (PD). Thus, a methodical strategy that concentrates on these infections as well as the pathogen-caused neuroinflammation and neurodegeneration may offer treatments for neurodegenerative diseases. To treat, manage, or prevent these conditions, antiviral/antimicrobial medications, vaccines, immunotherapies, and novel treatments (such as stem cell therapy) must collaborate. Better SARS-CoV-2 vaccines, new antiviral/antimicrobial medications, efficient immunotherapies (alpha-synuclein antibodies, vaccinations for PD or parkinsonism, etc.), as well as novel therapeutics, are projected to be created and made accessible in the future as medical research and technology evolve.

Author(s) Details:

Jing Zhang,
Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, MO 63110, US.

Please see the link here: https://stm.bookpi.org/CODHR-V2/article/view/7750

A Case Series of Seizures in Pediatrics with COVID-19 Disease | Chapter 16 | Recent Developments in Medicine and Medical Research Vol. 12

 The coronavirus outbreak began in China in December 2019 and quickly spread throughout the world. In children, these disorders can cause respiratory and gastrointestinal symptoms, although neurological signs such as seizures are infrequent. In addition, there is no precise information on how the neurological system manifests in youngsters. The goal of this case series investigation is to diagnose COVID-19 in children who have nervous system symptoms. Seizures in children with coronavirus infection are more likely to be severe and life-threatening, indicating a dismal prognosis.

Author(S) Details

Borhan Moradveisi
Cancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Shirin Behzadi
Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Avat Karimi
Department of Pediatrics, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Farima Zakaryaei
Kurdistan University of Medical Sciences, Sanandaj, Iran.

View Book:- https://stm.bookpi.org/RDMMR-V12/article/view/4682