Showing posts with label growth retardation. Show all posts
Showing posts with label growth retardation. Show all posts

Thursday, 19 June 2025

Assessment of Complementary Food Situation in Sierra Leone: Nutritional Problems and Possible Strategies | Chapter 6 | Current Perspectives in Agriculture and Food Science Vol. 9

The objective of this review was to discuss the complementary food situation and its Nutritional problems and possible strategies in Sierra Leone. Premature weaning, early solid food introduction, low nutrient density and bulkiness of supplemental meals, and unsanitary weaning techniques expose infants to increased mortality, illness, and malnutrition.  In most West African countries, especially in Sierra Leone, the use of a variety of home-made complementary foods prepared from locally grown foodstuffs during the weaning process is popular, with products traditionally known as pap (mesh rice water) fofo from cassava that is soaked for several days in water to ferment and remove the cassava and pound it, ogi or akamu (is a fermented cereal pudding made from maize (Zea mays), Sorghum (Sorghum bocolor ) or millet (Panicum miliaceum L.) gari (this is from cassava (Manihot esculenta) but that is crater into flaks and scotch on fire), and couscous (Triticum durum).

 

Sierra Leone is one of the countries in West Africa that has been reported to have a challenging situation with regard to complementary foods, little effort has so far been made to improve the situation. Despite these challenges, very little work has been directed towards the development of complementary foods using local foodstuffs as practiced in some other African countries. This situation has a serious impact on the lives of infants in Sierra Leone, thus increasing the rate of mortality in the country. The complementary food situation in Sierra Leone was reviewed in terms of the past and present practices as well as the types of complementary foods used in Sierra Leone.  Formulation of a highly nutritious formula and traditional food processing processes like fermentation and germination were suggested as a means of producing homemade supplementary foods throughout the nation. These methods are straightforward and may be easily implemented at the household and community levels without requiring complex technology. Commercially fortified foods for infants and young children (e.g., vitamin or mineral-enriched cereals) can also be an important source of micronutrients in some contexts.  However, the promotion of affordable fortified complementary foods should always be undertaken in line with national and global standards (i.e., the International Code of Marketing of Breast-milk Substitutes. Nonetheless, it was recently reported that a product from the orange-flesh sweet potato could address the issue of complementary food in the country as it is easy to prepare, and the products are easily available in rural areas and even urban settings. Other recommendations made include community nutrition education, the development of a weaning recipe book, reduction in the workload of the suckling mother, promotion of breastfeeding, and increased maternity leave period, which were suggested to be the most immediate possible strategies for the problems highlighted.

 

Author (s) Details

Philip John Kanu
Milton Margai Technical University, Goderich, Freetown, Sierra Leone, Institute of Food Technology, Nutrition and Consumer Studies, School of Agriculture and Food Science, Njala University, Sierra Leone and Centre for Development and Food Safety, 6 Earl Street, Freetown, Sierra Leone.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/cpafs/v9/2344

 

Thursday, 15 May 2025

Teratogenic Effects of Lixisenatide: Anatomical Malformations and Histopathological Changes in Developing Chick Embryos | Chapter 7 | Medical Science: Recent Advances and Applications Vol. 4

Background: Lixisenatide is a peptide containing 44 amino acids, which is amidated at the C-terminal amino acid. At present Lixisenatide is the drug been used to treat type 2 diabetes mellitus. Therapeutically is been considered to be best for treatment of diabetes mellitus than other GLP1 receptor antagonists. However, there is limited available data about effect of lixisenatide on liver, kidney, stomach and cerebral cortex. Studying the teratogenic effects of lixisenatide is important for human welfare.

Objectives: This study aims to find out gross anatomical malformations due to teratogenic effects of antidiabetic drug Lixisenatide on developing chick.

Methods: It was an Interventional study conducted at the Department of Anatomy, Santosh Medical College, Ghaziabad, India. It is confirmed from the literature survey/ pilot study that the expected mean ± SD of the parameter of control and experimental groups are 27±5.32 with 32±5.30, with the help of software G* Power analysis for α 5% and Power (1-β) 95.36%. The effect size is 1.961, and the sample size for each group is 28. So, we have taken the total sample size of 280. Descriptive statistical analysis, which included frequency and percentages, was used to characterise the data. Inferential statistics included a chi-square test and an independent samples t-test for different dependent variables of the study, and p<0.05 was considered statistically significant.

Results: Gross anatomical malformation was seen after administration of lixisenatide as compared to the control group. Histological sections D and Dd (magnified at 10X and 40X, respectively) of the liver treated with a higher dose of lixisenatide on embryonic day 21 show congestion of the central vein accompanied by infiltration of inflammatory cells. The most common anatomical malformation was growth retardation followed by limbs deformity and twisted neck and it was statistically significant (p<0.05) significant decrease in the weights of treated chick embryo compared to the control groups (p<0.05).

Conclusion: The findings generated in this study show teratogenic effects like anatomical malformations and histopathological changes due to effects of high dose of Lixisenatide on developing chick embryo in liver organ and these teratogenic effects may be extrapolated to human being.

 

Author (s) Details

Yogesh Yadav
Department of Anatomy, Noida International Institute of Medical Sciences, Noida, Uttar Pradesh, India.

 

Amit Kumar Srivastava
Department of Anatomy, Santosh Medical College, Gaziabad, Uttar Pradesh, India.

 

Ashok Kumar Gupta
Department of Anatomy, Government Medical College, Saharanpur, Uttar Pradesh, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/msraa/v4/2168