The Use of Membrane Lipid Replacement with Glycerophospholipids to Gradually Decrease the Self-Reported Symptom Severities in Chemically Exposed | Chapter 1 | Medical Science: Trends and Innovations Vol. 13

Approximately 700,000 United States armed forces personnel, along with armed forces from 30 coalition countries, were deployed to the Persian Gulf in 1991-1992 for support of military operations (Operation Desert Shield/Operation Desert Storm) that are now known as the 1991 Gulf War. A large fraction of veterans of the 1991 Gulf War slowly developed multi-symptom chronic illnesses that have been termed Gulf War Illnesses (GWI).  Many, if not the majority, of these GWI patients were chemically exposed, and they now have few alternatives for the treatment of their symptoms. Membrane Lipid Replacement (MLR) with oral membrane glycerophospholipids has been used as a safe and effective approach for slowly extracting and removing hydrophobic organic molecules from cells and tissues by the process of chemical partitioning into phospholipid structures and exchange by a mass action process. In addition, MLR also enhances mitochondrial function. This combination treatment can decrease the severity of certain signs and symptoms associated with a variety of multi-symptom illnesses, including those environmental illnesses associated with chemical contamination. A preliminary open-label study was conducted on 20 male veterans who were deployed to combat areas in Kuwait and Iraq during the 1991 Gulf War and were exposed to toxic chemicals. These veterans subsequently became ill with GWI and were utilised in this pilot study. This clinical study was designed as an open-label, Institutional Review Board-approved, preliminary or pilot clinical trial to study the effects of an all-natural glycerophospholipid chewable wafer supplement (Patented Energy® with NTFactor® Lipids) on the severity of signs and symptoms of GWI patients over a 6-month period.   The subjects took 6 g per day of the all-natural, oral MLR glycerophospholipids, and the severities of over 100 signs and symptoms were self-reported at various times using illness survey forms. Sixteen subjects in the study were fully compliant and completed the study.  There were gradual and significant reductions of symptom severities in these patients in categories related to fatigue, pain, musculoskeletal, nasopharyngeal, breathing, vision, sleep, balance, urinary, gastrointestinal symptoms and chemical sensitivities. During the Gulf War, veterans were variously exposed to a number of chemical, biological, and radiological sources, in addition to physical and mental stressors. In addition, GWI patients were exposed to combinations of multiple agents and stressors, and this makes any treatment approach much more complex. During the study, there were no adverse incidents, and the study supplement was extremely well tolerated. It is concluded that MLR with moderate amounts of oral glycerophospholipids appears to be a safe, simple and potentially effective method for slowly reducing the severity of multiple symptoms in chemically exposed veterans with multi-symptom illnesses (GWI). In addition, MLR also enhances mitochondrial function. This treatment was successfully used to slowly decrease the severity of certain signs and symptoms of chemically exposed veterans of the 1991 Gulf War.

 

Author (s) Details

 

Garth L. Nicolson
Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.

 

Paul C. Breeding
Department of Molecular Pathology, The Institute for Molecular Medicine, Huntington Beach, CA 92647, USA.

 

Please see the book here:- https://doi.org/10.9734/bpi/msti/v13/5127

Detoxification Capacity and Protective Effects of Medicinal Plants against Heavy Metals in Polluted Human Systems: A Recent Study | Chapter 10 | Current Aspects in Pharmaceutical Research and Development Vol. 7

 The study's main purpose was to prescribe certain herbal formulae as supplements in contaminated human cultures in order to lessen the negative effects of heavy metals that were present. The concentrations of various heavy metals, as well as the various mechanisms by which these metals were introduced into the body system, were determined in the Abu Qir, Amreyya, and Abis districts. Heavy metals can be absorbed into the body in a variety of ways, including through food, beverages, skin contact, and inhaled air. A herbal assemblage (ACOSTU) was constructed based on the types of heavy metals and their concentrations. The findings of a six-month herbal assembly application revealed a considerable improvement in the medical evaluated cases documented in the study locations. The study stated that as part of a long-term development strategy to safeguard vulnerable rural communities, the introduction of health-care-specific programmes for people living in contaminated areas is crucial.

Author(S) Details

Mardi M. Algandaby
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Khadiga M. Al-Hadead
Department of Environmental Science, Faculty of Natural Resources, Omar Al-Mokhtar University, Libya.

Salama M. El-Darier
Botany and Microbiology Department, Faculty of Science, Alexandria University, Alexandria, Egypt.

View Book:- https://stm.bookpi.org/CAPRD-V7/article/view/5419

Study on Detoxification Effect of Fermentation on Cyanide Content of Cassava Tuber | Chapter 14 | New Innovations in Chemistry and Biochemistry Vol. 1

 The goal of this study is to look into the detoxifying capability of fermentation on cassava tuber's poisonous (cyanide) content. Cassava is a staple food for roughly 800 million people in tropical countries. The cyanogenic glycosides in the tuber, which are mainly starch, are degraded by enzymes to form hydrocyanic acid. The fermentation procedure involves soaking newly peeled cassava tubers and fermenting grated cassava tubers, resulting in two fermentation treatments. Fermentation treatments were performed every two days using 20g of sample portions of fresh cassava tuber (UM 8082), which contained as much as 160.46mg/HCN/kg of tuber at the start. The pH of the medium was measured on a daily basis in order to correlate it with ongoing events. The HCN was analysed using the Knowles and Watkin's steam distillation method (Hydrogen cyanide). According to the results of the experiments, there was a significant drop or reduction of this poisonous principle in the tuber. HCN elimination was shown to be greatly aided by a long fermentation period (5 to 6 days) and a pH medium of 4.0 to 4.5. In fact, 94.7 percent (8.45 Mg/kg) and 81.3 percent (28.70 Mg/kg) reductions were achieved for soaking and grated cassava tubers, respectively. Because these values are less than the acceptable limit of 30 mg/kg for safe cyanide levels in food, fermentation is an excellent (and cost-effective) approach for detoxifying cassava tuber for human consumption.

Author (S) Details

G. N. Iwuoha
Department of Pure and Industrial Chemistry University of Port Harcourt, Rivers State, Nigeria.

G. G. Ubeng
Department of Pure and Industrial Chemistry University of Port Harcourt, Rivers State, Nigeria.

U. I. Onwuachu
Department of Chemistry, Nwafor Orizu College of Education Nsugbe, Anambra State, Nigeria.

View Book :- https://stm.bookpi.org/NICB-V1/article/view/3357

Update on Ketamine Infusion Therapy for Sustained Opioid Cessation for Chronic Pain and for Depression | Chapter 9 | Current Topics in Medicine and Medical Research Vol. 10

 Objectives: Opioid abuse and opioid use disorders (OUD) continue to threaten the veteran population of America with chronic opioid use estimates of over 28 percent for non-cancer pain . Long-term opioid cessation is the primary consequence of the original analysis using ketamine-assisted opioid detoxification, whereas secondary results are evaluations of opioid withdrawal, pain relief, and side effects of ketamine. The composite outcomes to date are also checked in this update. Design: Preliminary retrospective analysis requiring a systematic examination of a database that has been collected prospectively. Setting: Veterans Affairs Medical Center in Nashville, Tennessee; report from Franklin, TN, private practice clinic. Subjects: 41 veterans with chronic non-cancer pain and chronic opioids who underwent opioid detoxification aided by ketamine; update contains 114 patient results. Methods: The authors analyzed a real-time data set of forty-one patients who met the criteria for inclusion. Data collected over a 28-month period April 2016-July 2018) was reviewed by the authors. Following detoxification and the initial ketamine infusion sequence, patients were tracked for up to 12 months after infusion at regular intervals, extending this monitoring duration to October 2018 to ensure that all patients had at least 3 months of follow-up results. 

Results: Long after therapy, most veterans stayed opioid-free: 83%, 75%, and 58% at one, three, and six months, respectively (p=0.0001). Seventy-six percent of patients reported either no or moderate severity of opioid withdrawal. At one and three months, median pain declines were 50 percent and 40 percent respectively. The frequency of alarming side effects of ketamine was poor.

Conclusion: Overall, this update offers new proof that the use of a standardized procedure for ketamine infusion combined with rapid detoxification of opioids is quite successful, results in a high rate of sustained reduction of opioids, reduces chronic pain, minimizes withdrawal of opioids using purely non-opioid analgesics, and reduces depressive symptoms. A randomized controlled trial may be used in future research, but blinding patients and clinicians could be difficult. Opioid detoxification aided by ketamine tends to be a safe and efficient method for targeting opioid addiction and has the potential to decrease opioid consumption, deaths associated with overdose, and chronic pain.


Author (s) Details

Randall J. Malchow
VA Tennessee Valley Healthcare System, USA and AMG Ketamine and Wellness Center, USA.

Jennifer W. Baker
VA Tennessee Valley Healthcare System, USA

Ashley P. Yost,
VA Tennessee Valley Healthcare System, USA.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/323