Neutropenic
enterocolitis (NE), commonly known as typhlitis, is a serious illness that
primarily affects immunocompromised people. This is Armenia's first documented
case of NE. In September of this year, a 12-year-old girl was diagnosed with
Hodgkin Lymphoma IIA and began chemotherapy with prednisolone, vincristine,
doxorubicin, and etoposide. She developed gastrointestinal pain, cramps, and
constipation on the ninth day of chemotherapy. The results of the tests were
unremarkable. A gastroenterologist recommended empiric Helicobacter Pylori (HP)
eradication (a regimen of amoxicillin and clarithromycin). She had a fever two
days later, and her CBC revealed severe neutropenia (WBC -0.34 neutrophil
levels 0.06*103/L). For febrile neutropenia, Meropenem was prescribed. Despite
medication, the problems persisted. NE was suspected based on the symptoms
(fever, neutropenia, abdominal pain, and diarrhoea), and an abdominal CT scan
was conducted. It indicated a 0.5-1.0 cm breadth of intestinal mucosa. As a
result, the diagnosis of NE was confirmed, and the clarithromycin was replaced
with metronidazole. Blood culture revealed Pseudomonas aeruginosa, while stool
culture revealed Proteus vulgaris. The patient was able to recover after ten
days of antibiotic medication and a change in diet. CONCLUSION: Raising
typhlitis awareness and identifying potential risk factors in local
institutions may assist to reduce the prevalence and severity of the disease.
Author (S) Details
Tatevik Grigoryan
The Hematology Center
after Prof. Yeolyan, Ministry of Health of Armenia, Armenia.
Petros Ghazaryan
The Hematology Center after Prof. Yeolyan, Ministry of Health of Armenia,
Armenia.
Samvel Danielyan
The Hematology Center after Prof. Yeolyan, Ministry of Health of Armenia,
Armenia.
Gevorg Tamamyan
The Hematology Center after Prof. Yeolyan, Ministry of Health of Armenia,
Armenia.
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Book :- https://stm.bookpi.org/TIPR-V11/article/view/3133
Monday, 6 September 2021
Study on Confirmed Case of Neutropenic Enterocolitis in Armenia | Chapter 11 | Technological Innovation in Pharmaceutical Research Vol. 11
Monday, 4 January 2021
Comparison of Widal Screening Test with Cultural Isolation Method for Diagnosis of Salmonella typhi/paratyphi Infections | Chapter 7 | Recent Progress in Microbiology and Biotechnology Vol. 4
The efficacy of Widal screening was tested in comparison with stool and blood cultures for the diagnosis of typhoid/paratyphoid fever in exposed subjects. A total of 1000 samples from 248 males and 252 females aged < 1 - 68 years (500 stools and 500 blood each) were examined. A broad screening test was performed on the blood using commercial antigen, following the instructions of the manufacturer. The isolation and detection of species from blood and stool samples has been carried out using standard methods. Using polyvalent sera, characterization was performed and verified using single factor sera. Levels of retrieval of S. In the different Widal antibody titres, paratyphi A, B, C and typhi D were assessed from stool and blood cultures of positive subjects. Positive for S. among the subjects The isolation rate from stool was 37.5 percent at 1:160 large titers of O and H variants, while 39.1 percent of each subject combined was isolated from both blood and stool at 1:80 titers. For those who were hopeful for S. The isolation rates from stool and blood sample cultures combined were 46.7 percent at 1:160 positive titres, paratyphi B. Paratyphi C's 1:320 positive titers had peak isolation rates (41.7 percent) single from blood samples. In the instance of S. The peak isolation rate (47.4 percent) of typhoid D was 1:320 from the blood. Among the rates of S isolates, there was a substantial difference (P= .001). Typhi D, with Widal screening, from blood, stool and stool/blood cultures. There was no connection, however, between the data (r= .256, .309 and .235 respectively). Blood culture is an essential aid in the early stages of infection for the recovery and isolation of the organism. Stool culture can also be used as a diagnostic technique, although not very precise. Widal test, although it is also sensitive to only a screening process, but only results that produce high titles are accurate.
Author(s) Details
Dr. Clara Idara Eleazar
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