Studies of the Zwitterionic Buffer for the Biological pH Range: 2-hydroxy-3-[[2-hydroxy 1,1bis(hydroxymethyl) ethyl]amino]-1-propane sulfonic Acid (TAPSO) from (278.15 to 328.15)K|Chapter 1 | Current Research Progress in Physical Science Vol. 8

The present study highlights buffer standards for the physiological pH of the zwitterionic buffer 2-hydroxy-3-[[2-hydroxy-1, 1-bis (hydroxymethyl)ethyl)] amino]-1-propanesulfonic acid (TAPSO) from 278.15 to 325.15 K. The values of the second dissociation constant, pK₂, and related thermodynamic quantities of (TAPSO) have already been reported at 12 temperatures over the temperature range 5 to 50^oC, including 37^oC (body temperature) from this laboratory (Roy et al., 1997). Now this paper reports the results of the conventional paH for five buffer solutions without the chloride ion and also five buffer solutions with NaCl at ionic strength (I = 0.16 mol.kg^-1) similar to blood plasma and other physiological fluids in the temperature range 278.15 to 325.15 K. Electromotive force (emf) measurements and the extended Debye-Hückel equation have been used for the calculation of the values (designated as paH). The operational pH values for five buffer solutions at 278.15 K and 325.15 K have been calculated using the values of the residual liquid function potential (δEj) between the TAPSO buffer solutions and the blood phosphate primary buffer standard. The values of the δEj of these buffer solutions were obtained using the saturated KCl calomel electrode of the flowing junction cell. These three zwitterionic buffer solutions of TAPSO are recommended as primary pH standard reference solutions for pH measurements of the saline media (I = 0.16 mol kg-1), the clinical fluids such as blood serum. The results will be widely used in biochemical assays and pharmaceutical sciences.  The consistency of three sets of experimental data listed in Table 9 leads credibility in the pH values of these TAPSO buffer solutions.

 

Author (s) Details

 

Lakshmi N. Roy
Hoffman Department of Chemistry, Drury University, Springfield, USA.

 

Rabindra N. Roy
Hoffman Department of Chemistry, Drury University, Springfield, USA.

 

Blake M. Bodendorfer
Hoffman Department of Chemistry, Drury University, Springfield, USA.

 

Zachary M. Downs
Hoffman Department of Chemistry, Drury University, Springfield, USA.

 

Stephen D. Rocchio
Hoffman Department of Chemistry, Drury University, Springfield, USA.

 

Jessica M. Stegner
Hoffman Department of Chemistry, Drury University, Springfield, USA.

 

Isaac B. Henson
Hoffman Department of Chemistry, Drury University, Springfield, USA.

 

Please see the book here:- https://doi.org/10.9734/bpi/crpps/v8/3471

Role of Sulphur Containing Heterocycles in Medicinal Chemistry | Chapter 8 | Recent Developments in Science and Technology for Sustainable Future

Numerous applications of heterocyclic chemistry can be found in daily life. In the structure of heterocyclic compounds are heteroatoms such as oxygen, nitrogen, and sulphur. Numerous heterocyclic molecules that contain sulphur as a heteroatom have important physiological characteristics and practical medical uses.
 
Sulphur-containing heterocyclic compounds are considered a significant category due to their broad therapeutic applications like antibacterial, antimalarial, anticancer, antifungal, anti-HIV, and anti-inflammatory. This study focuses on the basic structure, properties, and synthesis of thiirane, thietane, thiophene, thiazole, and benzothiophene compounds and their biological importance.

Author(s) Details:

Pooja Sethi,
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana –Ambala- 133207, Haryana, India.

Ketan Vashisht,
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana –Ambala- 133207, Haryana, India.

Khushi Sharma,
Department of Chemistry, Maharishi Markandeshwar (Deemed to be University), Mullana –Ambala- 133207, Haryana, India.

Please see the link here: https://stm.bookpi.org/RDSTSF/article/view/13390