Development of Oral Herbal Male Contraceptive | Chapter 08 | Current Aspects in Pharmaceutical Research and Development Vol. 8

 

Background: More study on male contraception is encouraged since population management is seen as a key step toward global health. Despite the fact that there are many synthetic contraceptives available, they all have different negative effects. When compared to condoms, several male contraceptive treatments, such as hormonal, pharmacological, and immunological therapies, were researched over a long period of time and found to have good antifertility efficacy with low failure rates.

The idea of herbal contraceptives, which are an effective technique to limit animal and human reproduction, is the emphasis of this chapter. The focus of this review was on herbal medicinal plants and plant extracts that have been found to have antifertility effects in men. Plants having reported animal research and some with human studies for antifertility effects, as well as their dosages, chemical contents, and mechanism of action for the antifertility impact of the plants, are all considered in the review. This chapter also covers the stages of sperm formation, hormone production, and the mechanism of male contraceptives.

Conclusion: In terms of the current review's applicability, it might be extremely useful in the development of plant monographs and recommendations for their use. Many of the plants listed here could be used as alternative oral fertility regulators in males. As a result, greater research into the chemical and biological characteristics of these less-explored plants is needed to evaluate their contraceptive efficacy as well as any negative effects, so that these compounds can be utilised reliably to manage male fertility. New inventions are needed in this field to focus on more current, more potent pharmaceuticals with less toxic components that are self-administerable, less expensive, and entirely reversible.

Author(S) Details

Akash Yadav
IEC University, Baddi, Himachal Pradesh-174103, India.

Shivangi Sharma
Saraswati College of Pharmacy, Gharuan, Mohali, Punjab-140413, India.

Shahid Nazir Wani
IEC University, Baddi, Himachal Pradesh-174103, India.

Kirti Kaushal
IEC University, Baddi, Himachal Pradesh-174103, India.

Priya Sharma
IEC University, Baddi, Himachal Pradesh-174103, India.

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Investigating the Effect of Ethanolic Extract of Trigonella foenum-graecum L. Seeds on Reproductive System of Male Albino Rats | Chapter 6 | Highlights on Medicine and Medical Research Vol. 7

 The purpose of this chapter is to evaluate the antispermatogenic and antifertility properties of an ethanolic extract of Trigonella foenum-greacum seeds. It is one of the most extensively utilised plants for the treatment of numerous diseases in various traditional medical systems.

Methodology: An aqueous extract solution (250 mg/kg b.wt/day) was given orally to adult male albino rats for 45 days (Duckray strain).

The seeds extract inhibited spermatogenesis and made it impossible for normal untreated female rats with confirmed fertility to mate. The absolute and relative weights of the testis and seminal vesicle decreased significantly, whereas the weights of the ventral prostate and coagulating gland remained unchanged. In the cauda epididymis, sperm concentration and motility were likewise reduced. In the epididymal smear, there was a higher incidence of spermatozoa head and tail parts being separated. The testis of experimental animals demonstrated a halt in spermatogenesis at the secondary spermatocyte stage, as well as cellular debris buildup in the semineferous tubular lumen. The spermatids were underdeveloped, and the interstitial cells were thin and deteriorated. The spermatogonia, on the other hand, showed no signs of injury. Animals' body weight was not affected by extract administration. The levels of hallmark testicular enzymes, such as sorbitol dehydrogenase, were found to be much lower, whereas lactate dehydrogenase and gamma-glutamyl transpeptidase were significantly higher.

Conclusion: These findings imply that T. foenum-greacum can cause male infertility in rats and should therefore be investigated further as a possible male antifertility agent.

Author(s) Details

Madhulika Singh
Department of Zoology, School of Science, Maharishi University of Information Technology, Lucknow -226013, India.

G. N. Verma
Department of Zoology, University of Lucknow, Lucknow-226006, India.

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