Wound Healing Effects of Panchavalkal Ointment on Mechanically Induced Wounds in Wistar Albino Rats | Chapter 8 | Pharmaceutical Research - Recent Advances and Trends Vol. 2

 

Introduction: Panchavalkal is a well-known Ayurvedic poly-herbal formulation that has been reported to be used against inflammation, cleaning ulcers, and other types of wounds. Wounds affect a large proportion of the population worldwide most especially children in rural areas. However, little attention is always given to this health concern. In the experiment, one group received sesame oil to act as a positive control, another group received no intervention, acting as a negative control, while the remaining two groups received Panchavalkal ointment as treatment groups.

Aims and Objectives: To investigate the wound healing activity of Panchavalkal ointment on mechanically induced wounds in Wistar rats.

Material and Methods: Wistar strain albino rats of both sexes weighing 180 to 220g were used for the experiment. The rats were divided into four groups each consisting of six rats. A total of 24 rats were used for the whole study.

Statistical Analysis: One way analysis of variance (ANOVA) was used to compare the mean values of quantitative variables among the groups followed by Dunnett’s multiple ‘t’ test.

Observations and Results: Sesame oil and Panchvalkal ointment showed almost similar wound healing effects in comparison to control group which received no intervention.

Discussion: Panchavalkal ointment showed a statistically highly significant percentage of contraction of the excision wound area as compared to the negative control. Epithelization period was significantly decreased in sesame oil and Panchavalkal ointment (treatment groups).

Conclusion: Panchavalkal ointment decreased the pain, tenderness, redness, and swelling of the wounds which helped to control infection on the wounds and enhanced the rate of wound healing in albino rats. Therefore Panchavalkal ointment has anti-inflammatory, antibacterial and wound-healing properties.

 

Author(s)details:-

 

Vaikhari Dhurve
Department of Shalya Tantra, IPGT&RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.

 

Pravin Jawanjal
Department of Rasa Shastra and Bhaishajya Kalpana, IPGT&RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.

 

Mukesh Naria
Department of Pharmacology Laboratory, Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.

 

Tukaram Dudhamal
Department of Shalya Tantra IPGT&RA, Gujarat Ayurved University, Jamnagar, Gujarat, India.

 

Please See the book here :- https://doi.org/10.9734/bpi/prrat/v2/141

Study on the Synthesis and Antimicrobial Assay of Some Novel 4-Thiazolidinone Derivatives Possessing Benzofuran, Quinoline and Pyrazole Moieties | Chapter 10 | Current Perspectives on Chemical Sciences Vol. 4

This article describes simple, fast and convenient syntheses of six novel 4-thiazolidinone derivatives (3a-f) containing benzofuran, quinoline and pyrazole moieties. In the first step, six separate carbohydrazides (2a-f) were synthesised with 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (2) and six separate 2-(p-tolyloxy)quinoline-3-carbaldehyde-3-carbohydrazide (2) reactions (1a-f). Similarly, 5-(benzofuran-2-yl)-N'-(2-(2-(p-tolyloxy) substituted quinoline-3-yl)-4-oxothiazolidin-3-yl)) is replaced in the second stage by 5-(benzofuran-2-yl)-N'-(2-(p-tolyloxy) Through the interaction of 2a-f with thioglycolic acid in the presence of anhydrous zinc chloride, -1-phenyl-1H-pyrazole-3-carboxamide (3a-f) was prepared with excellent yield. Structural product 2a and 3a identifications are recorded on the basis of IR, 1H NMR, 13C NMR and Mass spectra and the analytical data obtained support the structure of the title compounds. In addition, these new products have been screened as the two preferred bacterial strains and two fungi such as C. albicans and A. niger using paper disc diffusion methods for their antimicrobial screening against S. aureus and E. coli. Antimicrobial screening has shown that the compounds are good antibacterial agents, but they have been found to be fungal inactive. In conclusion, the synthesis of some new 4-thiazolidinone derivatives with good yields of benzofuran, quinoline and pyrazole moieties, characterised by elemental and spectral studies such as IR, 1H NMR and mass spectra, has been published. Antimicrobial study of these synthesised compounds demonstrated improved bacterial activity but were ineffective against selected fungi.

Author (s) Details

Dr. M. Idrees
Department of Chemistry, Government Institute of Science, Nagpur (M.S.), 440001, India.

Dr. Y. G. Bodkhe
Department of Chemistry, Government Science College, Gadchiroli-442 605, India.

Dr. N. J. Siddiqui
Department of Chemistry, Government Institute of Science, Nagpur (M.S.), 440001, India.

View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/352