Holistic Management of Peptic Ulcer Disease: A Multidisciplinary Perspective | Chapter 5 | Achievements and Challenges of Medicine and Medical Science Vol. 11

Peptic ulcer disease (PUD) is a global health problem, affecting millions of people worldwide. An infected individual has an estimated lifetime risk of 10 -20% for the development of peptic ulcer disease, which is at least 3-4-fold higher than in non-infected subjects. PUD, characterized by mucosal erosions in the stomach or duodenum, remains a prevalent health issue. This review provides a comprehensive overview of both conventional and alternative treatment strategies. Proton pump inhibitors (PPIs) are the mainstay of pharmacotherapy, effectively reducing gastric acid production and promoting ulcer healing. H2 receptor antagonists serve as alternatives, inhibiting histamine-induced acid secretion. For Helicobacter pylori infections, antibiotic regimens are essential for eradication and recurrence prevention. Symptomatic relief and mucosal protection are further supported by antacids and cytoprotective agents. In addition to these conventional treatments, alternative therapies such as Ayurvedic, herbal, and homeopathic approaches have gained attention. Ayurvedic treatments often focus on dietary modifications and herbs like licorice (Glycyrrhiza glabra), known for its ulcer-healing properties. Herbal remedies, including aloe vera and deglycyrrhizinated licorice (DGL), have shown the potential to reduce ulcer symptoms and promote healing. Homeopathy offers remedies like Nux vomica and Carbo vegetabilis, aimed at relieving symptoms based on individual constitutions. Lifestyle changes, including minimizing NSAID use, alcohol, and smoking, complement these therapies. For complicated or refractory cases, surgical interventions, such as vagotomy or partial gastrectomy, may be necessary. Peptic ulcer disease (PUD) is a significant health concern due to its potential for complications and its impact on quality of life. Understanding the multifaceted nature of PUD necessitates a holistic approach that considers various factors beyond traditional medical interventions.

 

Author (s) Details

 

Pradnya Deolekar
Department of Pharmacology, D Y Patil Medical College, Navi Mumbai, India.

 

Kavitha Dongerkery
Department of Pharmacology, D Y Patil Medical College, Navi Mumbai, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/acmms/v11/3896

A Review Study on Screening of Non-Steroidal Anti-Inflammatory Drug Using Experimental Animal Models for Inflammatory Diseases| Chapter 4 | Current Overview on Pharmaceutical Science Vol. 2

 The objective of the study is to review on current available hide methods for judgment of non-steroidal anti-inflammatory drug(s) utilizing experimental animal models. Inflammation is a open innate internal defence system that plays a vital duty in healing processes. But the excessive answer of inflammation grant permission lead to serious energy problems cruel body. In such cases, miscellaneous anti-angering drugs such as steroidal and non-steroidal, are being used from long time to treat inflammatory unhealthy conditions. But the use of these medicines has existed associated with weighty side effects and toxicities and thus skilled is a need to investigate novel anti-angering drugs that were having middling side effects. As per reports various animal models are secondhand for preclinical studies using more recent medicines to evaluate and control possible antagonistic-inflammatory effects. There are various experimental in vivo models that were arbitrary for assessing pharmacological anti-instigative activities. However, selecting an appropriate animal model for integral evaluation of anti-instigative effects is completely found to be fault-finding enough. This chapter produced current issues in connection to in vivo animal models utilizing for hide of non-steroidal anti-angering drugs. These screening methods too involves pathophysiological studies for instigative conditions of each model respectively.

Author(s) Details:

Nidhi Agrawal,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)-495009, Chhattisgarh, India.

Meenakshi Jaiswal,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)-495009, Chhattisgarh, India.

S. K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (C.G.)-495009, Chhattisgarh, India.

Please see the link here: https://stm.bookpi.org/COPS-V2/article/view/9166