Colon Directed Drug Transport by Way of AZO Prodrugs | Chapter 4 | Challenges and Advances in Pharmaceutical Research Vol.1

 In the treatment of colonic disorders such as inflammatory bowel disease, ulcerative colitis, Chron's disease, chronic pancreatitis, and colonic carcinomas, oral medicine delivery to the colon becomes critical. The duration spent in the gastrointestinal tract (GIT), GI environment, microbial flora, and enzymatic degradation, among other biological variables impacting oral drug administration, are all blocking drug delivery. One of the most useful strategies for delivering medications to the colon via the oral route is the prodrug strategy. Due to the selective breaking of the azo link by azoreductases discharged by the gut microbiota, azo prodrugs of 5-Amino Salicylic Acid (5-ASA), 4-ASA, anticancer drugs, and novel leads useful in colonic illnesses have been examined in this work for colon directed drug delivery.

Author(s) Details:
Sanmati K. Jain,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG) 495009, India.


Sanjay K. Lanjhiyana,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG) 495009, India.


Bharti Ahirwar,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG) 495009, India.


Ajay Gupta,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG) 495009, India.


B. G. V. S. Jagan,
Department of Pharmacy, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG) 495009, India.


Ioannis S. Vourdoubas,
Consultant Engineer, 107B El. Venizelou str., 73132, Chania, Crete, Greece.

Please see the link here: https://stm.bookpi.org/CAPR-V1/article/view/6235

In vitro Release Study of Drug from Nano Particle | Chapter 8 | Challenges and Advances in Chemical Science Vol. 3

 Nanoscience and nanotechnology have seen tremendous progress in research and applications in recent years. There is growing hope that nanotechnology, when used to medicine, will lead to substantial advancements in illness diagnosis and treatment. Drug delivery, both in vitro and in vivo diagnostics, nutraceuticals, and the development of more biocompatible materials are all expected applications in medicine.

Carbon nanomaterials have been extensively investigated for biological and medicinal applications in recent years due to their many unique intrinsic physical and chemical properties. The work reported here is a first step in using Carbon Nano fibres as a vehicle for medication delivery to specific areas. The release of the anti-cancer medication Doxorubicin from functionalized Carbon Nano fibres was examined at various temperatures and pH levels. In an acidic media, a loaded anticancer medication releases more effectively. Furthermore, when the temperature rises, so does the amount of release.

Author (S) Details

Seema Manchanda
Department of Chemistry, B. K. Birla College of Arts, Science and Commerce (Autonomous), Kalyan, Maharashtra, India.

View Book :- https://stm.bookpi.org/CACS-V3/article/view/2954