Method Development and Validation for Simultaneous Estimation of Tapentadol and Paracetamol in the Bulk and Pharmaceutical Dosage Form by UV Spectrophotometry | Chapter 9 | Pharmaceutical Research: Recent Advances and Trends Vol. 8

A simple, rapid, accurate and precise UV Spectrophotometric method was developed for the simultaneous estimation of tapentadol (TAP) and paracetamol (PCM) in the pharmaceutical dosage forms. This method utilizes 0.1N hydrochloric acid (HCl) as solvent. Absorption maxima (max) of tapentadol and paracetamol was found to be 272.5 nm and 244.0 nm respectively, but we selected 257 nm for paracetamol, because at this wavelength tapentadol is showing linear absorbance values. Linearity was observed in the concentration range of 4-28 µg/ml for both the drugs. The R2 value was found to be 0.9991 and 0.9986 for tapentadol and paracetamol respectively. The method was validated statistically and by recovery studies. The mean percentage recovery was found to be between 95% - 105% for tapentadol and paracetamol.

 

Author (s) Details

P. Naresh
Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velikatta (Vi.), Kondapak (Mdl) Siddipet (Dist.) Pin – 502277, Telangana (St.), India.

 

Manjunath.S.Yalagatti
Department of Pharmaceutical Analysis and Quality Assurance, Srikrupa Institute of Pharmaceutical Sciences, Velikatta (Vi.), Kondapak (Mdl) Siddipet (Dist.) Pin – 502277, Telangana (St.), India.

 

V. Padmabhushana Chary
Department of Pharmaceutical Analysis, Anurag Pharmacy College, Kodad-508206, Telangana, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v8/3001

UV Spectrophotometric Method Development and Validation for Estimation of Trimetazidine Dihydrochloride in Bulk and Pharmaceutical Dosage Form | Chapter 2 | Pharmaceutical Science: New Insights and Developments Vol. 1

The present study illustrates the development and validation of a new, simple, precise and accurate spectrophotometric method for the determination of Anti-anginal Trimetazidine dihydrochloride (TMZ) in bulk and its dosage forms using Ethanol as solvent. The drug showed its λ max at 233 nm in various concentrations. Under the optimised conditions, linear relationships with good correlation coefficients were found between the concentration ranges of 10-60 µg/ml. The precision of the method was found to be <2% of %RSD. The accuracy of the method was found in the normal ranges i.e., the recovery values were found to be in the range of 97-101%. The LOD and LOQ values of the method were found to be 0.15 and 0.45 µg/ml, respectively. The assay of the method was found in normal values of 98.87%. The proposed method is practical and valuable for its routine application in quality control laboratories for the estimation of TMZ.

 

Author (s) Details

 

G. Sandhya Rani
Department of Pharmaceutical Analysis, Anurag Pharmacy College, Ananthagiri (Vi & Md), Kodad-508206, Telangana (St.), India.

 

L. Phanishabareesh
Anurag Pharmacy College, Ananthagiri (Vi & Md), Kodad-508206, Telangana (St.), India.

 

G. Shiwathmika
Anurag Pharmacy College, Ananthagiri (Vi & Md), Kodad-508206, Telangana (St.), India.

 

SK. Roshan Himad
Anurag Pharmacy College, Ananthagiri (Vi & Md), Kodad-508206, Telangana (St.), India.

 

M. Chinnaeswaraiah
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (Vi & Md), Kodad-508206, Telangana (St.), India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v1/3370