The Use of Computational Tools to Investigate the Impact of SARS-CoV2 Spike Protein Variants on Human Antibodies | Chapter 10 | Research Perspectives of Microbiology and Biotechnology Vol. 4

 

Understanding the process of formation of the complexes between Spike protein variants that make up the structure of the SARS-CoV2 virus and human antibodies, brings light into how variations have an impact on this complex formation. In this work, databases such as CoV3D, PDB and pyDockWEB were used to collect sequencing results and structures of SARS-CoV2 variants. Finally, molecular docking was also used in order to predict the interaction between the virus' Spike protein and antibodies. These results were then made available on a website produced exclusively for public dissemination of these analyses. Among other answers, this work serves as a guideline for molecular docking studies of the interaction between Spike protein variants and human antibodies.

 

 

Author(s) Details

Sérgio Amorim de Alencar

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

Rickson Passos Campoe

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

Yasmin Rezende

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

Rute Pereira de Souza

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

 

Please see the link:- https://doi.org/10.9734/bpi/rpmab/v4/1106

The Use of Computational Tools to Investigate the Impact of SARS-CoV2 Spike Protein Variants on Human Antibodies | Chapter 10 | Research Perspectives of Microbiology and Biotechnology Vol. 4

 

Understanding the process of formation of the complexes between Spike protein variants that make up the structure of the SARS-CoV2 virus and human antibodies, brings light into how variations have an impact on this complex formation. In this work, databases such as CoV3D, PDB and pyDockWEB were used to collect sequencing results and structures of SARS-CoV2 variants. Finally, molecular docking was also used in order to predict the interaction between the virus' Spike protein and antibodies. These results were then made available on a website produced exclusively for public dissemination of these analyses. Among other answers, this work serves as a guideline for molecular docking studies of the interaction between Spike protein variants and human antibodies.

 

 

Author(s) Details

 

Sérgio Amorim de Alencar

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

Rickson Passos Campoe

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

Yasmin Rezende

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

Rute Pereira de Souza

Postgraduate Program in Genomic Sciences and Biotechnology, Catholic University of Brasília, Brasília-DF, Brazil.

 

Please see the link:- https://doi.org/10.9734/bpi/rpmab/v4/1106

Role of Changes in SARS-CoV-2 Spike Protein and its Human Interaction and Nutritional Impact and Dental and Health Hygiene | Chapter 2 | Current Innovations in Disease and Health Research Vol. 8

 Nutrition is important in supporting the immune scheme. Immune homeostasis is actually well-regulated by a balanced food. It is key in the armament against viral threats. The realm has been tense of a pandemic for more than a period, humanity is agony great losses. Millions of nation have died, and nations have been in proper lockdowns to stay cautious which has experienced to the greater economic and friendly loss. The bacterium that turned the world over is refer to as the sars COV 2 virus usually known as the coronavirus. Aim of this review search out the aim of this study search out determine the mutation(s) in the series of the spike protein of the SARS-CoV-2 that maybe favoring human to human transmission and to decide nutritional act.

Author(s) Details:

Tarig Ginawi,
Biochemistry Department, College of Medicine, University of Ha’il, Saudi Arabia.

Fehaid Muqbil Alshammari,
Hail General Hospital, Saudi Arabia.

Ibtihag Siddig Elnaem Mohamed-Nour,
Oral and Maxillofacial Surgry, College of Dentistry, University of Ha'il, Saudi Arabia.

Rania Abdeen Husin Abdalla,
Department of Obstetrics and Gynecology, College of Medicine, University of Ha'il, Saudi Arabia.

Abeer, Hassan Elhaj,
Department of Community Medicine, College of Medicine, University of Ha'il, Saudi Arabia.

Gamal Eldin Mohammed Osman Elhussein,
Pediatric Department, College of Medicine, University of Ha'il, Saudi Arabia.

Firas S. Azzeh,
Depaprtment of Clinical Nutrition, Applied Medical Science, Umm Al-Qura University, KSA.

Amal Dhar,
Department of Community Medicine, College of Medicine, University of Ha’il, Saudi Arabia.

 
Ahmed Fathy Abdou Abbas,
General Practitioner, Hail University Medical Clinics, Saudi Arabia.

Fahmida Khatoon,
Biochemistry Department, College of Medicine, University of Ha'il, Saudi Arabia.

 
Mohamed Essam Eldin Ahmed Ghonim,
Department of Internal Medicine, College of Medicine, University of Ha'il, KSA and Department of Internal Medicine, Faculty of Medicine, Zagazig University, Egypt.

Please see the link here: https://stm.bookpi.org/CIDHR-V8/article/view/12408