Showing posts with label Frozen section. Show all posts
Showing posts with label Frozen section. Show all posts

Thursday, 12 October 2023

Frozen Section Diagnosis: An Emphasis on Reasons, Accuracy and Errors for Discordance | Chapter 6 | Novel Research Aspects in Medicine and Medical Science Vol. 5

The purpose of the hearing was comparing rates of intra-functioning frozen section disease with last diagnosis on paraffin section in consideration of assess concordant, conflicting, and postponed diagnosis rates and to label the causes of discordance. The links of intra-operative stopped section diagnosis accompanying permanent section definitive diagnosis is a important aspect of surgical pathology control of product quality. A retrospective analysis of 117 cases of stopped section biopsy was completed activity which were stated in the Histopathology department between July 2007 to June 2012.  The equivalence between the frozen division diagnosis with ending histological diagnosis was acted in order to check the accuracy of the method.  The number and type of discrepancies were compared, causes for the conflicts were analysed in order to decrease the avoidable mistakes and improve on the stopped section diagnoses. The overall accuracy of stopped section diagnoses over 5years was 90.60% with fake positive rate of 0.85%, false negative rate of 6.84% and 1.71% of delayed diagnosis. Sensitivity was 87.69% and Specificity was 98%. The conflicts were mainly due to the understanding error, sampling wrong and technical artefacts. Gross inspection, pathologist sample, stopped sections linked with cytological and histological analysis, and cooperation among consultants can help to escape few restrictions and give intensely, trustworthy, and inexpensive information needed favorable possible patient treatment.

 Author(s) Details:


Roopam Kishore Gidwani,
Pathology Department, Medical College Vadodara, India.

Falguni Jay Goswami,
Pathology Department, Medical College Vadodara, India.

Arpan Mehta,
Neuberg Supratech Reference Laboratory, Ahmedabad, India.

Nirali V. Shah,
Pathology Department, Medical College Vadodara, India.

Shobhana Prajapati,
Pathology Department, Medical College Vadodara, India.

Manisha M. Shah,
Pathology Department, Medical College Vadodara, India.

Thursday, 14 April 2022

Determining the Value of Intra-Operative Frozen Section in Thyroid Neoplasm Management | Chapter 12 | New Horizons in Medicine and Medical Research Vol. 4

 The purpose of this study is to evaluate the value of the frozen section (FS) in the management of patients with thyroid disease, as well as to share our personal experiences with it after thyroid surgery.

In this retrospective investigation, the outcomes of 1110 frozen sections of thyroid tissues analysed during a ten-year period from 2003 to 2012, as well as their linkages with the final histological evaluation, were examined. Deferred replies were not taken into account in statistical calculations.

Results: In our investigation, FS and the final histological diagnosis concurred in 85.4 percent of patients, whereas 5.5 percent differed. 9.1% of the cases were placed on hold. The global specificity and sensitivity of FS analysis were 99.3 percent and 64.7 percent, respectively, for all histological subtypes. It detected papillary cancer with a 61.7 percent sensitivity, follicular carcinoma with an 83.3 percent sensitivity, and anaplastic carcinoma with a 100 percent sensitivity. The disparities were caused by six false-positive (FP) diagnoses and 55 false-negative (FN) diagnoses. Fifty percent of the FN was papillary microcarcinoma. The FS exam has a positive predictive value (PPV) of 94.4 percent and a negative predictive value of 93.9 percent (NPV).

Conclusions: The utility of intraoperative FS in the confirmation of thyroid nodule malignancy is supported by our findings. It's associated with good specificity and a reasonable sensitivity rate. The majority of the inconsistencies between FS and ultimate histological diagnosis were explained by papillary microcarcinoma. Pathologists and surgeons could benefit from a standardised language in their evaluations and decision-making in the operating room.


Author(S) Details


Nihed Abdessayed
Department of Pathology, Habib Thameur Hospital, Tunis, Tunisia.

Raja Jouini
Department of Pathology, Habib Thameur Hospital, Tunis, Tunisia.

Wafa Koubba-Mahjoub
Department of Pathology, Habib Thameur Hospital, Tunis, Tunisia.

Ehsen ben Brahim
Department of Pathology, Habib Thameur Hospital, Tunis, Tunisia.

Achraf Chadli Debbiche
Department of Pathology, Habib Thameur Hospital, Tunis, Tunisia.

View Book:- https://stm.bookpi.org/NHMMR-V4/article/view/6374