Screening of Bioactive Secondary Metabolites and Free Radical Scavenging Activity of Mucuna pruriens Seeds | Chapter 8 | Novel Aspects on Pharmaceutical Research Vol. 1

 The purpose concerning this chapter search out identify Mucuna pruriens beginning extract's bioactive phytoconstituents and quantify allure in vitro antioxidant activity.Preliminary phytochemical reasoning were done for the discovery of bioactive constituents utilizing standard procedures and the DPPH (2, 2-diphenyl-1-picrylhydrazyl) test was used to judge the In vitro antioxidant activity.Mucuna pruriens source extract was subjected to a preliminary phytochemical study, that revealed the appearance of major bioactive substances like phenols, flavonoids, tannins, alkaloids, triterpenes, and phytosterols. The maximum DPPH radical scavenging activity of Mucuna pruriens beginning extract in an antioxidant experiment was 72.95%, compared to a maximum action of 93.24% for the standard control at the same quantity (0.2 mg/ml). This is a blatant sign of the drug's forceful antioxidant properties.Mucuna pruriens sources are abundant source of natural antioxidants and presented high DPPH radical scavenging characteristics and contains main bioactive phytoconstituents. such as phenols, flavonoids, tannins, alkaloids, triterpenes, and phytosterols.

Author(s) Details:

R. Rajesh,
Phulo Jhano Medical College, Dumka, Jharkhand, India.

V. Sreekala,
Regional Institute of Ayurvedic Research, Gwalior, India.

Dhananjay Srikant Kostastane,
Autonomous State Medical College, Gonda, 271001, India.

Please see the link here: https://stm.bookpi.org/NAPR-V1/article/view/10306

Phytochemical Composition and Antioxidant Activity of Flavonoid-Rich Extracts of Elsholtzia ciliata Collected in Dak Lak Province, Vietnam | Chapter 2 | Current Overview on Pharmaceutical Science Vol. 6

 Elsholtzia ciliata (Thunb.) Hyland (Lamiaceae) is widespread in the Central Highlands (Tay Nguyen) and Southern Vietnam. In traditional cure, E. ciliata has been secondhand for the treatment of colds, frenzy, flu, difficulty, dizziness, rheumatism, pharyngitis, intestinal pain, dysentery, vomiting, measles, and itching sores. This study proposed to determine the total flavonoid content by excited liquid extraction plan and evaluate the antioxidant action of flavonoid-rich extracts of E. ciliata collected in the three domains in Dak Lak province. The flammable liquid extracts were obtained by enthusiastic liquid extraction plan from the leaves of E. ciliata composed in Buon Ma Thuot city (KG-BMT), Cu M'gar section (KG-CM), and Buon Don district (KG-BD). The total flavonoid content (TFC) from the intoxicating extracts obtained in three domains was 82.30696 mg quercetin equivalent (QE)/g extract for the Cu M'gar region, 62.26035 mg QE/g extract for the Buon Don district, and 27.08587 mg QE/g extract for Buon Ma Thuot city. The flammable liquid extracts showed extreme levels of antioxidant capacity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay accompanying IC50 ranging from 0.70 to 1.98 mg/mL. Flavonoid compounds were recognized as apigenin, apigenin-O-b-glucoside, ethyl gallate, catechin, epicatechin, and quercitrin from the methanol extracts in three domains by extreme-high performance liquid chromatography (UHPLC).

Author(s) Details:

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam and Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, 167 Hoang Ngan, Cau Giay District, Hanoi 11313, Vietnam.

Truong Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Van-Tinh Nguyen,
Applied Biomedical Research Institute Buon Ma Thuot University of Medicine, 298 Ha Huy Tap Street, Buon Ma Thuot, Dak Lak, 630000, Vietnam.

Dam Thi Bich Hanh,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Truong Ba Phong,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Phi-Hung Nguyen,
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi 122100, Vietnam.

Manh Hung Tran,
School of Medicine & Pharmacy, The University of Danang, Hoa Quy, Ngu Hanh Son, Da Nang City 550000, Vietnam.

Please see the link here: https://stm.bookpi.org/COPS-V6/article/view/9460

Isolation, Characterizations of Bioactive Principles from Melia dubia Leaf and Its In-silico and In-vitro Urolithiatic Activity | Chapter 1 | Current Perspectives on Chemical Sciences Vol. 11

 Many medicinal plants contain a wide range of bioactive compounds at various levels. The primary goal of this research is to identify and separate antioxidants from different extracts of Melia dubia leaves. Soxhlet extraction was used with solvents such as hexane, chloroform, ethyl acetate, methanol, water, and 70% ethanol. The anti-oxidant capacity of six extracts was determined using the simple and convenient DPPH method. Extracts with high scavenging activity Separation was achieved using chromatographic techniques, which were then characterized using spectral methods. In-silico and in-vitro testing were performed on compounds with the highest antioxidant efficacy to determine their inhibitory potential against Urolithiatic activity. Methanol and ethanol have antioxidant activity. The antioxidant potential of 70% ethanol extracts was higher, and two antioxidants, MDL-1 and MDL-2, were isolated and characterized. MDL-1 had a higher scavenging potential than MDL-2, and its antiurolithiatic properties were confirmed using molecular docking (Insilico) and the single diffusion gel method (In-vitro).

Author (S) Details

Dr. J. Rosaline Vimala
PG & Research Department of Chemistry, Holy Cross College (Autonomous), Tiruchirappalli, India.

Dr. G. Dayana Jeyaleela
PG & Research Department of Chemistry, Holy Cross College (Autonomous), Tiruchirappalli, India.

View Book :- https://stm.bookpi.org/CPCS-V11/article/view/1570