In-silico and In-vitro Antimitotic Activity of Some Novel 6-Fluoro-1, 2, 4-Triazolo-Benzothiazole Analogues | Chapter 5 | Advanced Concepts in Pharmaceutical Research Vol. 5

Worldwide, cancer is a leading cause of death in both developed and developing countries. Numerous natural and manmade anticancer drugs treat solid tumors, lymphomas, and leukemias in different forms. In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, an in-silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Thin-layer chromatography (TLC) was used to monitor the progress of the reaction progress. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazole-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazole-benzothiazole analogues in inhibiting the proliferation of cancer cells either by promoting microtubule formation or affecting microtubules, thereby preventing microtubule breakdown. The obtained results suggest that germinated mung beans may be a useful tool for quickly and affordably evaluating new medicines' cytotoxic effects.

Author(s) Details:

Naresh Podila,
Department of Pharmaceutical Sciences, Vignan's Foundation for Science, Technology and Research, Guntur, Andhra Pradesh, 522213, India.

Sanapala Arun Kumar,
Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, Rangareddy, Telangana, 500001, India.

Vijaya Kishore K.,
Department of Pharmaceutical Sciences, College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, Andhra Pradesh, 522510, India.

Rajashekar V.,
Department of Pharmaceutical Chemistry, Anurag Pharmacy College, Ananthagiri, Kodad, Suryapet, Telangana, 508206, India.

Risy Namratha Jamullamudi,
Department of Pharmaceutical Regulatory Affairs, Siddhartha Institute of Pharmaceutical Sciences, Narasaraopeta, Andhra Pradesh, 522601, India.

Prasada Rao Manchineni,
Department of Pharmaceutical Analysis, Medarametla Anjamma Mastan Rao College of Pharmacy, Narasaraopet, Palnadu, Andhra Pradesh, 522601, India.

Namratha Sunkara,
Bharat Institute of Technology, Ibrahimpatnam, Rangareddy District, Telangana, 501506, India.

Sreelatha Muddisetti,
Vikas College of Pharmaceutical Sciences, Suryapet, Telangana, 508376, India.

Please see the link here: https://stm.bookpi.org/ACPR-V5/article/view/13245

Exploration of Newer Possibilities to the Synthesis of Diazepine and Quinoline Carboxylic Acid Substituted Analogues of Benzothiazolo Condensed Oxocarbazoles and Oxoazacarbazoles of Medicinal Interest | Chapter 3 | Challenges and Advances in Chemical Science Vol. 1

 Chemists have been drawn to heterocyclic systems containing benzothiazoles, carbazole (and azacarbazole) moieties because these nuclei have been identified in the literature as the most promising pharmacophores in drug design and synthesis. Based on these findings, it is reasonable to expect that incorporating the bioactive azepine and quinoline moiety into the molecular framework of benzothiazoles fused to carbazole (and azacarbazoles) would result in an intriguing series of compounds 9-12 with enhanced biological activities, the structure of which was unequivocally established by micro analyses and spectral data.

Author (S) Details

Vatsala Soni
Department of Chemistry, Banasthali University, Banasthali, 304022, Rajasthan, India.

Dr. Meenakshi Sharma
Department of Chemistry, Banasthali University, Banasthali, 304022, Rajasthan, India.

Vaishali Soni
SKRAU, Bikaner, Raj, 334001, India.

Shiv Lal Soni
PGIMER, Chandigarh, 160012, India.

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