Advancements in Therapeutic Drug Monitoring: Integrating Pharmacokinetics, Pharmacodynamics, and Bayesian Approaches for Personalised Medicine | Chapter 6 | Pharmaceutical Research: Recent Advances and Trends Vol. 9

 Therapeutic drug monitoring (TDM) is a critical process in clinical pharmacology that involves measuring drug concentrations in biological fluids to optimize drug dosage and ensure efficacy while avoiding toxicity. By incorporating pharmacokinetics (PK) and pharmacodynamics (PD) principles, TDM allows for individualized therapy, particularly for drugs with narrow therapeutic indices. Recent advancements, including population pharmacokinetic approaches and Bayesian estimation, have enhanced the precision of TDM. This review highlights the evolution of TDM, its role in optimizing patient outcomes, and emerging techniques such as pharmacodynamic monitoring to further individualize and refine therapeutic regimens.

 

Author (s) Details

 

V. Himabindu
Department of Pharmaceutics, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

G. Sangeetha Roy
Department of Pharmacy Practice, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v9/3134

Advancements in Therapeutic Drug Monitoring: Integrating Pharmacokinetics, Pharmacodynamics, and Bayesian Approaches for Personalised Medicine | Chapter 6 | Pharmaceutical Research: Recent Advances and Trends Vol. 9

 

Therapeutic drug monitoring (TDM) is a critical process in clinical pharmacology that involves measuring drug concentrations in biological fluids to optimize drug dosage and ensure efficacy while avoiding toxicity. By incorporating pharmacokinetics (PK) and pharmacodynamics (PD) principles, TDM allows for individualized therapy, particularly for drugs with narrow therapeutic indices. Recent advancements, including population pharmacokinetic approaches and Bayesian estimation, have enhanced the precision of TDM. This review highlights the evolution of TDM, its role in optimizing patient outcomes, and emerging techniques such as pharmacodynamic monitoring to further individualize and refine therapeutic regimens.

 

Author(s)details:-

 

V. Himabindu
Department of Pharmaceutics, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

G. Sangeetha Roy
Department of Pharmacy Practice, Anurag Pharmacy College (Affiliated to JNTUH, Hyderabad), Kodad, Telangana, India.

 

Please See the book here :-  https://doi.org/10.9734/bpi/prrat/v9/3134

Overview of Analytical Methods for Taxanes Quantification in Diluted Formulations and Biological Samples and their Applications in Clinical Practice | Chapter 3 | Technological Innovation in Pharmaceutical Research Vol. 11

 The purpose of this study is to examine the analytical methodologies for quantifying taxanes in diluted formulations and biological materials, as well as their clinical applications. Health professionals are currently concerned about improving the rational use of traditional chemotherapy medications, which remain an important method for cancer treatment. Taxanes are a class of chemotherapeutic drugs that are commonly used to treat a wide range of malignancies. Their delivery to patients is parenteral, which entails dilutions from commercial stock solutions in order to acquire the final individualised quantity of medicine prescribed, which is rarely validated. The lack of post-dilution quality control can lead to clinical response variability. The analysis of these diluted solutions is critical for ensuring precise content and, as a result, safe and effective treatment. Therapeutic drug monitoring, on the other hand, is required to optimise individual therapy of medicines having a small therapeutic window, such as taxanes. Drug measurement in plasma samples is critical for establishing pharmacokinetic characteristics that allow dose adjustment and assessing inter- and intra-individual metabolic variability, hence improving therapy efficacy while reducing side effects. As a result, methods for quantifying plasmatic concentrations of taxanes are crucial in clinical practise, helping to treatment individualization. For these goals, this study conducted a bibliographic survey and comparison of currently available analytical methodologies. For quantification of taxanes in hospital laboratories, high performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC-MS/MS), and micellar electro-kinetic chromatography (MEKC) analytical methods were considered and compared. It was concluded that, while LC-MS/MS is an extremely powerful technique, HPLC is versatile and cost-effective for both purposes.

Author (S) Details

Raquel A. Palmas
Requimte/Farma, University of Porto, Faculty of Pharmacy, Department of Drug Sciences, Laboratory of Pharmacology, Porto, Portugal.

Joaquim Monteiro
Requimte/Farma, University of Porto, Faculty of Pharmacy, Department of Drug Sciences, Laboratory of Pharmacology, Porto, Portugal and Health Sciences Research Center, Department of Pharmaceutical Sciences, Instituto Superior de Ciências da Saúde, Norte, Gandra, Portugal.

Paula Fresco
Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal.

View Book :- https://stm.bookpi.org/TIPR-V11/article/view/3125