Study of L-glutamic Acid's in situ Polymorphic Phase Transition through Solution Mediated | Chapter 11 | Novel Aspects on Chemistry and Biochemistry Vol. 9

 In the current work, we report the solution-mediated polymorphic conversion of L-glutamic acid from its metastable -α to stable state -β at various crystallization temperatures, including 5°C, 10°C, 20°C, and 30°C. L-glutamic acid (LGA) solution-mediated polymorphic transformation was observed using an optical microscope, and the gravimetric approach was used to analyze concentration changes that occurred during crystallization. Supersaturation change with respect to time during solution mediated polymorphic transformation was investigated. Solubility of L-Glutamic acid polymorphs in aqueous solution was determined by gravimetric method. It is found that the onset of the polymorphic transformation is manifested as the point in time when crystals of the stable β phase of L-Glutamic acid were first detected and elucidated. Only α-polymorphs nucleated and grew at the crystallization temperature of 5°C with the concentration of 4.5g/300ml rather β-polymorphs nucleated and grew in the temperature of 30°C. Solution mediated polymorphic transformation observed in the crystallization temperatures of 10°C and 20°C. The polymorphs obtained during the crystallization were analyzed by powder X-ray diffraction (PXRD) technique. The effect of time and temperature on the crystallization and solution mediated polymorphic transformation of L-Glutamic acid was intensely observed. The growth and dissolution behaviors of both polymorphs were investigated with time.

Author(s) Details:

P. Dhanasekaran,
Department of Physics, School of Distance Education, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/NACB-V9/article/view/13334

Effect of l-aspartic Acid Addition on Crystal Growth, Structural, Optical and Biological Applications of l-glutamic Acid Crystals | Chapter 6 | Novel Aspects on Chemistry and Biochemistry Vol. 3

 In the studies, we have successfully of age meta stable α polymorphs of l-glutamic acid sole crystal in the presence of l-asparic acid as an supplement by using the slow stable evaporation design. Amino acid compound have played a meaningful part in the improvement of technologically main materials because these elements are recognized for their fundamental, optical and material properties. The discriminating additive l-aspartic acid is additional at different concentrations into the l-glutamic acid liquid solution and the effect of the additive on l-glutamic acid polymorphs is inspected. It  makes that at a level of 0.03 g/100 ml aggregation, the additive donates to the crystallization of l-glutamic acid in α-form. Meta fixed α- L-glutamic acid crystal vicinity of L-aspartic acid was grown by slow dissolution method applied rather considerable completely clean properties against the eight pathogens that were checked and compared. The uncontaminated activity effect of mature metastable α- L-glutamic acid crystal in the presence of L-aspartic at various concentration (0.03 & 0.08 g/ 100 ml) is resolved in detail. Powder X-ray dissemination study of grown α crystal belongs to the orthorhombic crystal form. The UV-Vis spectral studies of α transparent have a high transparency range in the complete seeable region. The allotment of transmittance of of age a crystals is 82.12% individually. The impact of l-asparic acid on the antimicrobial action of the developed crystals was studied by promoting the agar diffusion order.

Author(s) Details:

J. Aarthi,
Department of Physics, Erode Sengunthar Engineering College, Erode- 638057, Tamil Nadu, India.

P. Dhanasekaran,
Department of Physics, School of Distance Education, Bharathiar University, Coimbatore-641046, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/NACB-V3/article/view/11025