Showing posts with label gastrointestinal bleeding. Show all posts
Showing posts with label gastrointestinal bleeding. Show all posts

Saturday, 4 April 2026

Dieulafoy’s Lesion as An Important Cause of Obscure GI Bleeding: A Case Report | Chapter 11 | Medical Science: Updates and Prospects Vol. 7

 

Dieulafoy's lesion is a rare but serious cause of gastrointestinal bleeding, typically affecting older adults. It involves an aberrant arteriole eroding the gastric mucosa, resulting in severe, recurrent bleeding that poses diagnostic and management challenges. A review of the literature revealed that, since the original description of Dieulafoy’s lesion over 100 years ago, only 280 cases had been reported worldwide up to 2010. From Bangladesh, only two cases have been reported, both described recently. This study reported the case of a female in her mid-sixties who presented with melena. She had coexisting left heart failure and chronic kidney disease. Initial and repeat upper GI endoscopies were negative, but a subsequent emergency endoscopy revealed bleeding from two sites near the gastroesophageal junction. Hemostasis was achieved with argon plasma coagulation, and Dieulafoy’s lesion was identified as the cause of her recurrent GI bleeding. This case highlights the importance of considering Dieulafoy’s lesion (DL) in the differential diagnosis of gastrointestinal haemorrhage, as it can cause significant morbidity, weight loss, and may be missed during initial investigations. Therefore, DL should be emphasised in postgraduate medical curricula and always considered in patients presenting with GI bleeding.

 

 

Author(s) Details

Mamun Al Mahtab
Department of Hepatology, Bangladesh Medical University, Dhaka, Bangladesh.

 

Sheikh Mohammad Fazle Akbar
Oita University, Oita / Miyakawa Memorial Research Foundation, Tokyo, Japan.

 

Musarrat Mahtab
Clinical Research Organization, Dhaka, Bangladesh.

 

Please see the book here :- https://doi.org/10.9734/bpi/msup/v7/7281

Saturday, 21 June 2025

Chronic Renal Failure and Bleeding Due to Dieulafoy Lesion: Two Case Reports and Literature Review | Chapter 10 | Medicine and Medical Research: New Perspectives Vol. 4

Dieulafoy’s lesions are rare vascular malformations of the gastrointestinal tract. Dieulafoy’s lesion was first reported by Gallard in 1884 and then described in detail by Georges Dieulafoy in 1898. A Dieulafoy’s lesion is an aberrant vessel that does not reduce in caliber when it extends from the submucosa to the mucosa. Damage to this artery can cause severe and intermittent arterial bleeding from small vascular stumps that are difficult to visualize. Multiple factors have been proposed that increase the risk of upper gastrointestinal bleeding in end-stage renal disease patients including platelet dysfunction due to uremia, high prevalence of arteriovenous malformations, various co-morbidities like cardiovascular disease, diabetes mellitus, liver cirrhosis and old age. Furthermore, these catastrophic bleeding episodes frequently result in hemodynamic instability and the need for transfusion of multiple blood products. Recently, uremic syndrome has been identified as a risk factor for gastric mucosal lesions. We present two clinical cases of acute digestive bleeding due to the Dielafoy lesion with chronic kidney disease as the main cause, where two different therapies were performed endoscopically. Endoscopic therapy is still the first-line diagnostic and/or treatment option for Dieulafoy’s lesion. This study concluded with the results of the patients that the best therapy was the application of the hemostatic hemoclip on the injury vs. the injection with adrenaline on the wound site. Uremia is identified as a risk factor for upper gastrointestinal bleeding in patients with pre-existing Dieulafoy lesions, as well as a higher incidence of new bleeding.

 

Author (s) Details

 

Gustavo Adolfo Hernández Valdez
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

Diana Estefanía Ibarra García
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

Juan Antonio Contreras Escamilla
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

Janette Alejandra Gamiño Gutierrez
Hospital Civil de Guadalajara Fray, Mexico.

 

Francisco Manuel Tonatiuh Carrillo Beltran
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

Ulises Solis Gomez
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

Jocelyn Nataly Quintero Meléndez
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

Ivan Alejandro Medina Jimenez
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

Marco Antonio González Villar
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

Jorge Rojas Morales
Department of Internal Medicine, ISSSTE APP General Hospital of Tepic, Tepic, Nayarit, Mexico.

 

 

Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v4/2410