Showing posts with label early onset. Show all posts
Showing posts with label early onset. Show all posts

Wednesday, 28 May 2025

Rising Trends in Early-Onset Colorectal Cancer: Epidemiological Insights and Future Directions in Multimodal Treatment and Prevention |Chapter 7 | Medicine and Medical Research: New Perspectives Vol. 9

People under the age of 50 are experiencing an increasing incidence of early-onset colorectal cancer (CRC), as well as an increasing mortality rate associated with the disease. This is a well-known fact. As a result of these patterns, a flurry of research has been conducted with the objective of elucidating the epidemiology and characteristics of colorectal cancer that manifests at an early stage, as well as developing strategies for early detection and prevention.

There are two methods that can be utilised in order to identify and prevent early-onset colorectal cancer (CRC) in young adults who do not exhibit any symptoms: There are two types of screening: 1) population-based screening for individuals who would otherwise be considered to be at average risk, and 2) precision screening, which takes into account factors such as genetics, lifestyle, and family history. Initiating early screening based on family history is the primary precision screening technique that is recommended for the early detection and prevention of early-onset CRC. This technique is also known as genetic screening.  However, the most important thing that should we do is early screening for this specific age group.

 

Author (s) Details

Budhi Ida Bagus
Department of Surgery, Sebelas Maret University, Indonesia.

 

Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v9/2487

 

Friday, 6 November 2020

A Report on Genetic Mapping in Papillon-Lefèvre Syndrome| Chapter 7 | Current Strategies in Biotechnology and Bioresource Technology Vol. 3

 Two cases of Papillon-Lefevre syndrome (PLS) in paediatric patients treated with a multidisciplinary approach have been identified in the current case series. Papillon-Lefevre syndrome (PLS) is an unusual heterogeneous autosomal recessive trait characterised by erythematous palmoplantar hyperkeratosis, periodontitis of early onset, and dura mater associated calcification. With genetic, immunological, and microbial factors playing a role in etiopathogenesis, the aetiology of PLS is multifactorial. The recently discovered PLS genetic defect was mapped to chromosome 11q14-q21, which includes cathepsin C mutations. This paper presents a report of 2 cases of Papillonlefevre syndrome in which diagnosis is based on clinical presentation and genetic mapping.PLS in an extremely rare condition is associated with lifelong psychological and social impacts on the growing children such as depression including hopelessness, aimlessness, social phobia, and a fear of communicating with people outside their family.


Author(s) Details

Dr. Priti A. Charde
Department of Periodontology and Implantology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra 442001,India..

Dr. Shweta Kale
Department of Prosthodontics, Sharad Pawar Dental College and Hospital, Wardha, Maharastra 442001, India.

Dr. M. L. Bhongade

Department of Periodontology and Implantology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra 442001,India.

Dr. Priyanka Jaiswal

Department of Periodontology and Implantology, Sharad Pawar Dental College and Hospital, Wardha, Maharashtra 442001,India.

Dr. Aniruddha M. Deshpande

Department of Periodontology and Implantology, CSMSS Dental College and Hospital, Aurangabad, Maharashtra 431136,India.

View Book :-
https://bp.bookpi.org/index.php/bpi/catalog/book/306