Patient-Centric Design in Orodispersible Films: Balancing Efficacy and Acceptability | Chapter 3 | Pharmaceutical Research: Recent Advances and Trends Vol. 8

Objective: This review paper aims to provide details on the preparation, characterization and evaluation of orodispersible films (ODFs). This review also aims to focus on the merit and demerits that affect film formulation and give an insight into potential drug candidates, and polymers used in ODFs.

 

Background: According to the ninth edition of the European Pharmacopoeia (Ph. Eur.), ODFs films are formulations that are intended for the delivery of drugs by oral administration via the oral cavity. From the past few decades, researchers and companies trying toward novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are an expensive, complex, and time-consuming process but trends are now moving toward novel drug delivery systems. This delivery system helps to get drug response by local and systemic action through different routes. This novel approach of preparing ODFs provides ease to pediatrics, geriatrics, and bedridden patients.

 

Findings: Regarding formulation, ODFs must have a pleasant taste, be of appropriate size, and be packed in suitable packing material. To ensure all these properties, drugs and excipients must have good stability, the required solubility and permeability, and the dose of the incorporated drug must be small dose with a low molecular weight (MW). The manufacturing of ODFs is not an easy process and a number of techniques have been developed to manufacture them which have been discusses here. The characterization and evaluation of prepared ODFs is important, and numerous methods have been developed to assess prepared ODFs according to desired aims and objectives. Packaging of films is important to maintain stability during storage and retain the mechanical properties of ODF formulations.

 

Conclusion: ODFs are effective, safe, and bioavailable as compared to fast disintegrating tablets. The novel approach has various advantages because it provides effect instantly during the emergency condition and in schizophrenic and dysphasic patients without taking water and disintegrates within a few seconds in the oral cavity.  Solvent casting method is the most frequently used technique to develop ODFs by using film-forming polymers having fast disintegration time, improved drug dissolution and better drug content.

 

Author (s) Details

Ahmad Salawi
Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

 

Please see the book here:- https://doi.org/10.9734/bpi/prrat/v8/2531

Study on Preparation and Optimization of Fast Dissolving HPMC/PVA Blended films of Loperamide Hydrochloride | Chapter 12 | Technological Innovation in Pharmaceutical Research Vol. 10

 Because identifying new chemical entities is a difficult, expensive, and time-consuming process, the current tendency is to create and develop better drug delivery mechanisms for existing medications. Fast dissolving oral films have recently been introduced to the market, attracting the attention of many pharmaceutical companies due to their numerous advantages over other oral dosage forms, including ease of administration, better patient compliance, rapid drug absorption, and rapid onset of action with instant bioavailability. Aside from these benefits, youngsters, the elderly, and bedridden patients who have difficulty swallowing tablets or capsules can benefit from quick dissolving oral films. Fast-dissolving oral films comprising breath strips, confectionery, and dental care treatments were initially developed, but it has now grown into an unique and widely accepted way for delivering both OTC and prescription medications. As an alternative to fast-acting pills, fast-acting films are gaining popularity. When the films come into contact with a wet surface, such as the tongue, they breakdown in a matter of seconds, allowing the user to eat the food without needing any additional liquid. This ease of use has both a marketing and a compliance benefit for patients. The drug avoids gastrointestinal degradation and the first-pass effect because it is absorbed directly into the systemic circulation. The mouth dissolving film for Loperamide hydrochloride is made by solvent casting. Loperamide hydrochloride as an anti-diarrheal, HPMC-E50, HPMC-E15-LV, and PVA as film forming polymers, propylene glycol as a plasticizer, sodium starch glycolate (2-8%) as super disintegrant, lemon oil (2-5%) as a flavouring agent, citric acid (2-6%) as a Saliva Stimulating Agent, and methylparaben (0.015%) as a preservative were. The independent variables were tensile strength, disintegration time, and percentage drug dissolution, while the response variables were tensile strength, disintegration time, and percentage drug dissolution. The formulations were evaluated based on mass uniformity, thickness, percent drug content, folding endurance, surface pH, moisture uptake, percent swelling, percentage elongation, tensile strength, in vitro disintegration time, and in vitro percentage drug dissolution. Loperamide has been identified as a promising candidate for use in the creation of Fast Mouth Dissolving Films. Loperamide oral films are made using a simple and cost-effective solvent casting method. The super disintegrants utilised in this investigation thought it was acceptable. There was no physicochemical interaction found in FT-IR testing of drug-excipient compatibility. The oral films obtained were clear, had enough physical strength, and had a good disintegration time. All mixtures had a better release profile than pure medications in in vitro dissolution tests. The best formulation among the others is film formulation F7, which has a blend of HPMC E15 and PVA film formers, according to the test results.

Author (S) Details

Poonam Patil
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, Raigad Mumbai, (M.H.), India.

Vaishali Jadhav
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, Raigad Mumbai, (M.H.), India.

Rasika Rane
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, Raigad Mumbai, (M.H.), India.

Amruta Shelar
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, Raigad Mumbai, (M.H.), India.

Sainath Nair
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, Raigad Mumbai, (M.H.), India.

Aniruddha Gurchal
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, Raigad Mumbai, (M.H.), India.

Sujay Kanitkar
Konkan Gyanpeeth Rahul Dharkar College of Pharmacy & Research Institute, Karjat, Raigad Mumbai, (M.H.), India.

View Book :- https://stm.bookpi.org/TIPR-V10/article/view/2849