Acute Myeloid Leukemia: Current Therapy, Challenges, and Future Therapeutic Candidates | Book Publisher International

 Acute myelogenous leukemia (AML) is the most common leukemia among adults. It is characterized by somatic mutations or genetic alterations that lead to neoplastic changes and clonal proliferation. Historical treatment paradigms remained largely unchanged throughout the 20th and early 21st centuries, the current treatment of AML stills chemotherapy and stem cell transplantation. Even though advancements in understanding the genetic variances associated with AML have introduced promising new therapeutic options that could potentially improve the outcomes. Tyrosine kinase inhibitors (TKI) such as PKC-412 are one of the recent treatment options that showed successful results. However, in addition to the cost, evidence of resistance to these TKI has been reported. Therefore, searching for alternative, cheaper, available, and effective treatments for AML is vitally needed. This book aimed to be suitable for medical and biomedical students to understand the pathogenesis of AML in molecular aspects and the possible treatment of such malignancies. Therefore, the pathogenesis, therapeutic targets, challenges, and possible therapeutic candidates have been discussed in detail in this book.

Author(s) Details:

Hamid Ali Nagi Al-Jamal,
School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Terengganu, Terengganu 21300, Malaysia.

Belal Almajali,
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.

Maysa Alhawamdeh,
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Mutah University, Al-Karak, Jordan.

Hanan Kamel M. Saad,
School of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Kuala Terengganu, Terengganu 21300, Malaysia.

Please see the link here: https://stm.bookpi.org/AMLCTCFTC/article/view/12302

Polymers in the Formulation and Characterization of Amlodipine Besylate Oral Mouth Dissolving Films| Chapter 8 | Current Overview on Pharmaceutical Science Vol. 2

The purpose of the work was to plan oral dissolving films and reinforce the drug release of amlodipine besylate by the inclusion of synthetic and everyday polymers. The oral dissolving films intoxicated with Amlodipine besylate were arranged by solvent dissolution method utilizing hydroxy propyl methyl cellulose-3cps& 5cps, Blanose, methyl cellulose and tamarind children polyose by adding appropriate plasticizer: PEG 400 and glycerin. The prepared spoken dissolving films were evaluated for drug content, burden variation, diameter, pH, folding continuity, In vitro drug release and stability. The evaluation limits of Amlodipine besylate were found expected satisfactory in agreements of drug content, thickness and pH. Comparison of the dissolution descriptions of Amlodipine besylate oral disappearing films in phosphate buffer (pH 6.8). The release descriptions of films were analyzed by using UV- Visible spectrophotometer at 239nm. The improved formulation AML 15 death studies were Compared with clean drug and marketed expression. AML 15 showed the highest drug release 100% in 10min, when distinguished to pure drug 88.2% in 30min and displayed AML 92.2% in 45min. showed. Preformulation studies of amlodipine besylate like unity studies with polymers using FTIR, DSC studies were completed activity. The drug and polymers were found expected compatible accompanying each other. These results were strongly submitted that the water soluble polymers were acceptable for the formulation of spoken fast dissolving films of amlodipine besylate. Effective drug release was achieved for amlodipine besylate incidentally of preparation of spoken dissolving films by stable evaporation method.

Author(s) Details:

Pamula Reddy Bhavanam,
Department of Pharmaceutical Technology, Nirmala College of Pharmacy, Atmakuru, Andhra Pradesh-522503, India.

Shaik Abdul Rahaman,
Department of Pharmaceutical Technology, Nirmala College of Pharmacy, Atmakuru, Andhra Pradesh-522503, India.

M. Mohan Varma,
Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh-534202, India.

Please see the link here: https://stm.bookpi.org/COPS-V2/article/view/9170