It has been reported from recent scientific evidence that chronic
obstructive pulmonary disease (COPD) is not only an inflammatory/oxidative lung
alteration but also a multiorgan disease causing extrapulmonary manifestations
like cardiovascular disease, neurological degenerations, musculoskeletal
dysfunction and clinical depression. Experimental studies suggested that ozone
therapy has unique properties in reducing inflammation and upregulating the
cellular antioxidant system in chronic oxidative stress diseases.
To evaluate the effects of ozone as integrated therapy in the
treatment of COPD, we enrolled 80 patients affected by moderate/ severe COPD.
40 patients (Group A), in addition to standard therapy with inhaled
bronchodilator and/or corticosteroids, underwent a cycle of oxygen ozonetherapy
(major ozonated autohemotherapy, O3-AHT) twice a week for the first 5 weeks, thereafter
a single treatment every week for other 10 weeks. The resting 40 patients
(Group B) served as control and did not receive treatments otherwise the
standard therapy with inhaled LABA / LAMA and/or corticosteroids. In Group A
there was a significant increase in functional capacity assessed by 6 minutes
walking test (415 ±101.1 m before the study vs 493.8 ± 105.2 m at the end of
the study, p < 0.01) and a significant decrease in the degree of dyspnea
measured by Borg scale and an improvement of the quality of life as reported in
the results of Saint George Respiratory Questionnaire. The control group B
showed no significant difference before and after the study. Even if the
results of this study need to be confirmed with an ample clinical trial, the use
of ozone seems to be an effective treatment for the improvement of the quality
of life in COPD patients.
Author(s)
Details
Emma
Borrelli
Department of Medical Biotechnologies, University of Siena, Siena,
Italy.
Please
see the book here:- https://doi.org/10.9734/bpi/dhrni/v3/1777
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