Pyometra, a severe uterine infection, triggers a systemic inflammatory response characterized by elevated levels of acute phase proteins such as C-reactive protein (CRP) and Serum Amyloid A (SAA). The subsequent ovariohysterectomy, necessary for treating pyometra, introduces additional stress, further influencing these biomarkers and various biochemical parameters.
This chapter examines changes in CRP, SAA, and other biochemical
markers in female dogs diagnosed with pyometra compared to healthy controls.
The findings underscore the importance of monitoring these biomarkers for
diagnostic and management purposes, providing veterinarians with critical
information for effective treatment and care. The study highlights the
complexity of the acute phase response and its role in understanding the
broader implications of infection, inflammation, and surgical intervention in
veterinary practice.
Key observations include a significant increase in leukocytes,
fibrinogen, and CRP levels in dogs with pyometra. Additionally, a strong
positive correlation was found between CRP and fibrinogen, and between
fibrinogen and leukogram parameters. The study concludes that analyzing
leukocytes, fibrinogen, and CRP can be recommended as supplementary
examinations for diagnosing the inflammatory process in bitches with pyometra.
Furthermore, the research suggests potential novel applications of acute phase
proteins in monitoring stress and overall health in laboratory animal medicine.
Overall, this comprehensive examination provides valuable insights
into the systemic effects of pyometra and ovariohysterectomy, emphasizing the
significance of acute phase proteins as diagnostic and therapeutic targets in
veterinary medicine.
Author(s)
Details
Nejra Hadzimusic
Department of Clinical Sciences, Faculty of Veterinary Medicine,
University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Dzenita
Hadzijunuzovic Alagic
Department of Clinical Sciences, Faculty of Veterinary Medicine,
University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Please see the book here:- https://doi.org/10.9734/bpi/ibs/v10/1965
No comments:
Post a Comment