The pharmacokinetics of cefquinome are studied in different
animals such as camel, sheep, piglets, chicken, mice, dogs, pigs, and calves.
However, these studies are conducted in different parts of the world and there
is no data available from India. Therefore, this study aims to evaluate the
Pharmacokinetic parameters of Cefquinome in Marathwadi Buffalo Calves. An
experiment was performed on six healthy Marathwadi buffalo calves of either sex
of age above 6 months and weighing between 80 to 120 kg to study the different
pharmacokinetic parameters after a single intravenous administration @ 2 mg/kg
body weight by microbiological assay technique. After intravenous
administration of the drug, blood samples (4 ml each) of buffalo calves were
collected from the external jugular vein using disposable needles in clot
activator tubes at different time intervals. The schedule of blood collection
for pharmacokinetic studies after intravenous administration was at 0, 5, 10,
15, 30 min and 1, 2, 4, 6, 8, 10, 12 and 24 hrs. The serum levels of cefquinome
were estimated by microbiological assay technique using a large glass plate.
Different Pharmacokinetic parameters were calculated as described by different
scientists and analyzed by randomized block design, and the significance was
tested at 5% and 1% levels as per. The peak serum concentration, elimination
half-life, volume of distribution, total body clearance, absorption half-life
and area under curve values found were 1.74 ± 0.151 mcg/ml at 2.5 min of
sampling time, 1.97±0.14 h, 3.97 ± 0.83 L/kg (Vd(B)) and 2.86 ± 0.34L/kg
(Vdss), 1.11 ± 0.13 L/kg.h-1, 0.10 ± 0.02 h, and 1.93 ± 0.23
µg/ml/hr respectively. The bioavailability of cefquinome in buffalo calves was
found to be 165.38 %. It may be concluded that the elimination half-life of
cefquinome was 2.54 h in Marathwadi buffalo calves indicating the repeating of
doses at 12 to 15 h intervals in Marathwadi buffalo calves and the loading dose
would be double than the maintenance dose of cefquinome after intravenous administration.
The microbiological assay technique was found to be suitable for the estimation
of serum cefquinome concentration in laboratories where the LC/MS facilities
are not available.
Author(s)
Details
M. K.
Patil
College of Veterinary and Animal Sciences, Udgir Dist. Latur,
Maharashtra-413517, India.
A. P.
Somkuwar
Nagpur Veterinary College, Seminary Hills, Nagpur-440006,
Maharashtra, India.
Please see the book here:- https://doi.org/10.9734/bpi/ibs/v10/1206
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