A number of atenolol prodrugs were created using DFT, MP2, and hybrid GGA: MPW1k calculations for an acid-catalyzed hydrolysis of nine Kirby's N-alkylmaleamic acids. A linear association between the estimated and experimental rate values for the nine Kirby's N-alkylmaleamic acids has provided a solid foundation for developing atenolol prodrugs that are bitterless, stable in neutral aqueous solutions, and capable of releasing the parent drug in a sustained manner. The projected t1/2 values for atenolol prodrugs ProD 1-ProD 2 at pH 2 were 65.3 hours and 11.8 minutes, respectively, based on the computed B3LYP/6-31 G (d,p) rates. The t1/2 of the atenolol prodrug ProD 1 was found to be heavily influenced by the pH of the medium in an in vitro kinetic investigation. In 1N HCl, buffer pH 2, and buffer pH 5, the determined t1/2 values were 2.53, 3.82, and 133 hours, respectively.
Author (s) DetailsRafik Karaman
Faculty of Pharmacy, Al-Quds University, P.O.Box 20002, Jerusalem, Palestine.
Rafik Karaman
Faculty of Pharmacy, Al-Quds University, P.O.Box 20002, Jerusalem, Palestine.
View Book :- https://stm.bookpi.org/TIPR-V4/article/view/1494
No comments:
Post a Comment