Synthesis, Characterization and Biological Activity of Some Novel Substituted 1,3,4-Pyrazole Derivatives | Chapter 5 | Novel Aspects on Pharmaceutical Research Vol. 3

 In the study, a series of novel substituted 1,3,4-pyrazole derivatives were combined by the backlash of substituted acetophenones are condensed with hydrazides to the equivalent hydrazones. the development of novel descendants of pyrazoles and evaluation of their bioactivities have found a distinguished place in the drug discovery uses. All newly synthesized compounds were typified on the basis of IR, 1H NMR and Mass ghostly data and screened for their antioxidant and antagonistic-inflammatory activities. Among bureaucracy, compounds 4c and 4e exhibited important antioxidant activity in all the four arrangements comparable accompanying standard ascorbic acid. Compounds 4d and 4e showed significant antagonistic inflammatory venture comparable with standard drug diclofenac sodium utilizing carrageenan-induced informer hind paw edema system.

Author(s) Details:

Bono Naga Sudha,
Department of Pharmaceutical Chemistry, CES College of Pharmacy, Kurnool-518218, Andhra Pradesh, India.

N. Yella Subbaiah,
Department of Pharmaceutical Chemistry, Santhiram College of Pharmacy, NH-44, Nandyal-518112, Andhra Pradesh, India.

Manchala Mahalakshmi,
Department of Pharmaceutical Chemistry, CES College of Pharmacy, Kurnool-518218, Andhra Pradesh, India.

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