Inhibitory Effect of Burmannic Acid for Proliferation and Oxidative Stress Induce Responses of Oral Cancer Cells | Chapter 10 | New Advances in Medicine and Medical Science Vol. 3

 The present inquiry evaluated the antiproliferation effects of C. burmannii-derive BURA on oral malignancy cells for the first time. Oral tumor cell lines came from gin-gival, tongue, and buccal covering layer tissues (Ca9-22, CAL 27, and OC-2) were selected for testing the natural response to BURA. Oxidative stress in spoken disease is related to added systemic ailments in the body such as periodontitis, cardiovascular, pancreatic, stomachic, and liver diseases. In the review, we discuss the various pathways that intervene oxidative cellular damage. In terms of machine, BURA per- turbed cell phase distribution, upregulated mitochondrial superoxide, induced mitochondrial depo- larization, prompted γ H2AX and 8-hydroxy-2-deoxyguanosine DNA damage, and induced apop- tosis and caspase 3/8/9 incitement in oral cancer containers. N-acetylcysteine treatment confirmed oxidative stress as a key determinant in promoting antiproliferation, apoptosis, and DNA damage in spoken cancer cells.  The study showed that BURA generates oxidative stress and causes apoptosis and DNA damage that prevents oral cancer container proliferation.

Author(s) Details:

Su-Ling Liu,
Experimental Forest College of Bioresources and Agriculture, National Taiwan University, Zhushan Township, Nantou County-55750, Taiwan.

Kun-Han Yang,
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung-80708, Taiwan.

Che-Wei Yang,
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung-80708, Taiwan.

Min-Yu Lee,
Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung-80708, Taiwan.

Ya-Ting Chuang,
Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung-80708, Taiwan.

Yan-Ning Chen,
Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung-80708, Taiwan.

Chung-Yi Chen,
School of Medical and Health Sciences, Fooyin University, Kaohsiung-83102, Taiwan.

Please see the link here: https://stm.bookpi.org/NAMMS-V3/article/view/10778