Recent Development and Validation of a Dissolution Method for Lamotrigine Tablets by UPLC | Chapter 3 | Technological Innovation in Pharmaceutical Research Vol. 4

 The goal of this study was to design and validate a UPLC dissolve method for lamotrigine tablets that was accurate, precise, repeatable, and cost-effective. The UPLC technique was carried out with a 75:25 percent v/v mixture of buffer and acetonitrile. The flow rate was 0.3 ml/min, and the UV detection wavelength was 310 nm. Acquity UPLC BEH Shield RP18,2.1X50 mm column was used. The proportion of the assay was found to be 100.8. The procedure was successfully applied to commercial linearity was plotted from (100 g/ml to 300 g/ml) (r2 = 0.9979) Lamotrigene formulations and validated according to International Conference on Harmonization requirements. In the respectively, the approach was discovered to be linear. Percent relative standard deviation figures in the intra-day and inter-day precision studies were satisfactory, indicating that the procedure is exact. A search of the literature found that many analytical methods for estimating lamotrigene have been published, but no UPLC dissolution method for lamotrigine tablets has been developed and validated. The approach was extensively scrutinised in order to ensure the drug's stability during the analysis period.

Author (s) Details

S. Sangeetha
Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Salem -636008, Vinayaka Mission’s Research Foundation (deemed to be university), Tamilnadu, India.

S. Alexandar
Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Salem -636008, Vinayaka Mission’s Research Foundation (deemed to be university), Tamilnadu, India.

J. Loganathan
Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Salem -636008, Vinayaka Mission’s Research Foundation (deemed to be university), Tamilnadu, India.

B. Jaykar
Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, Salem -636008, Vinayaka Mission’s Research Foundation (deemed to be university), Tamilnadu, India.

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